DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and slc24a3

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_685302.4	Gene:	slc24a3 / 557196	ZFINID:	ZDB-GENE-090312-67	Length:	660	Species:	Danio rerio

Alignment Length:	716	Identity:	232/716 - (32%)
Similarity:	358/716 - (50%)	Gaps:	143/716 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 AKPRPAKQHFGG------------SNSNSPNQNQNHNDVLGGVGAPSQTSGEDEAEIMYPFQSGE 268
            |:.:..|:.|||            |..:|..:|       .|.|.|| .|.||..:    ::|..
Zfish    25 ARRKKRKELFGGQMCFMGLLLLAVSGLSSLAEN-------SGYGIPS-LSAEDSKK----WESRR 77

  Fly   269 --QMFGLEEDQEQDPELNSNAVPGSDEDNAGNQRGINDTHNDNSTTTKTPLFPKDLFTKEQLENG 331
              |.|.::.:...:.:|..||      |......||::             ||.|:||:::...|
Zfish    78 LLQDFDIDSNYTDEVQLGPNA------DKNCTPPGIHE-------------FPDDIFTQQERLEG 123

  Fly   332 AVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFV 396
            ||.||::..:|||.|||:|||::|||||:.|.|:|.:::|||||||||||.|||||||||||||:
Zfish   124 AVALHVLCAMYMFYALALVCDDYFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFI 188

  Fly   397 SFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFW 461
            :..|||:||||||||||||.:||:|.:|:...:.|:.|.|.||.::|:|::..||.|..|.::.|
Zfish   189 TKGDVGVGTIVGSAVFNILCIIGVCGIFTAQAVRLSCWTLMRDSTYYTIAVATLIVFIYDEKVTW 253

  Fly   462 WEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRVRSTDQLMPAGNAANSSETSMATQPGG 526
            ||:|||..:|:.|:..||:|.:|...:
Zfish   254 WESLILIVLYLVYILIMKFNSRVVHFI-------------------------------------- 280

  Fly   527 SVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGST--QTGAKFRHGLLQLMIHTIDPLHDGKVD 589
                    |.|...|.:...|...|:....|...:.  ...|.|......||           ||
Zfish   281 --------ERRKKNPANLGNGTASNTDIDDGCDATVVLLKKANFHRKPSVLM-----------VD 326

  Fly   590 EKATQL-HAI----ASLKVLLDATKPQRGGATTSAANHVKINLKETTLADR-PNGNIDTTLDSP- 647
            |..:.. |.:    |.:::::.:....|...|  .|:.:.|..::..:..| .||:.:.|:..|
Zfish   327 ELLSAYPHQLTFSEAGMRIMITSHFSPRTRLT--MASRMLITERQRLINSRFSNGDSEVTVKMPG 389

  Fly   648 -------------SLSGRRPSW-------------IEQRVKIQTRKFSIKAPEIEDEPEP--LSM 684
                         .|:||:...             .|...:......:.:..|.|||.|.  :..
Zfish   390 KRGVENGLAGPDRGLNGRKGGHHDDDRGGAEAGTDTENENEDNENNENDEEEEEEDENEGPYVPF 454

  Fly   685 AWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGD 749
            ..|.....:|.::|..||.:.::.|:|::..||.:|::.|:||.|.:|||.|||:|||...|.|.
Zfish   455 RCPGGGINKLKWLLAWPLSMLLFFTVPNSANPRWERWYMVSFISSTIWIAFFSYIMVWMVTVIGY 519

  Fly   750 TARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLL--YGI 812
            |..||..:||:||||||||:||.:.|:||||:|.||||:|:|:|||:||:.:||.:||.|  ..|
Zfish   520 TMGIPDVIMGITFLAAGTSVPDCLASLIVARQGMGDMAISNSIGSNVFDILIGLGLPWALQTLAI 584

  Fly   813 IYGAPVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVI 877
            .||:.:.:||.|::.|:.:|...:...|:.:....|:::|.|||...|:|..|:..|::.|:::.
Zfish   585 NYGSTIHLNSKGLIFSVGLLLASVFLTVLGVHLNNWKLDKRLGFACLLMYAVFLCFSILIEFNIF 649

  Fly   878 T 878
            |
Zfish   650 T 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	81/143 (57%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	70/151 (46%)
slc24a3	XP_685302.4	TIGR00367	127..637	CDD:273039	196/568 (35%)
		Na_Ca_ex	128..270	CDD:279963	80/141 (57%)
		Na_Ca_ex	491..643	CDD:279963	70/151 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820