Protein Alignment Nckx30C and SLC24A5

DIOPT Version :9

• Sequence 1: NP_652011.3
• Gene: Nckx30C / 45248
• FlyBaseID: FBgn0028704
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_995322.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 500
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 179/562 - (31%)
• Similarity: 278/562 - (49%)
• Gaps: 127/562 - (22%)

  Fly   318 FPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGG 382
            ||:..||:::..:|.:|::.:.::|||:|::|||||:|:|||::|.|.||::.||||.||||||.
Human    54 FPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGS 118

  Fly   383 SAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISL 447
            |||||.|:.:|||::..|:||.||:|||::|:|.:...|.|.|.||.:|:.|||||||:.|:||.
Human   119 SAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISA 183

  Fly   448 LVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRVRSTDQLMPAGNA 512
            ..::....||:::|:|..:|..||..||..:.:::::...:.|..:.......::.::
Human   184 AAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMER------- 241

  Fly   513 ANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTGAKFRHGLLQLMI 577
             :..:..|..:..|....|..|.|.||.....              ||.:|..... |||.|:.
Human   242 -SEQQPLMGWEDEGQPFIRRQSRTDSGIFYED--------------SGYSQLSISL-HGLSQVS- 289

  Fly   578 HTIDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGATTSAANHVKINLKETTLADRPNGNIDT 642
                                                                             
Human   290 ----------------------------------------------------------------- 289

  Fly   643 TLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMW 707
                                             ||.|...:|  |:...||:.:||..|::..::
Human   290 ---------------------------------EDPPSVFNM--PEADLKRIFWVLSLPIITLLF 319

  Fly   708 LTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDL 772
            ||.||.|....|.:|.:||..|.:||:||:|::||...:.|:|..||..|||||.|||||||||.
Human   320 LTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDT 384

  Fly   773 ITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLL-YGIIYG-APVEVNSVGMVCSITILFMM 835
            |.||:|||||.||||:|:.||||:||: :.|.|||.: ...|.| ||.||||.|:......|.:.
Human   385 IASVLVARKGKGDMAMSNIVGSNVFDM-LCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNIS 448

  Fly   836 LVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVI 877
            ::|:.:::....|::::.||....|.|.....:|:::|..:|
Human   449 IIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGII 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	71/143 (50%)
		Na_Ca_ex	721..871	CDD:279963	69/151 (46%)
SLC24A5	NP_995322.1	Na_Ca_ex	<20..>224	CDD:332332	77/169 (46%)
		Na_Ca_ex	<290..490	CDD:332332	86/202 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820