DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nckx30C and slc24a4

DIOPT Version :9

Sequence 1:	NP_652011.3	Gene:	Nckx30C / 45248	FlyBaseID:	FBgn0028704	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_002933272.2	Gene:	slc24a4 / 100489343	XenbaseID:	XB-GENE-478288	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	231/605 - (38%)
Similarity:	328/605 - (54%)	Gaps:	85/605 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GNQRGINDTHN------DNSTTTKT---PL---FPKDLFTKEQLENGAVILHIIGVIYMFVALAI 349
            |.::.::|..|      ||.|..|.   |.   ||.|||:.::.:.|||:.||...:|||.||||
Frog    59 GQEKLVSDWRNRRLLVSDNGTQAKNCTEPAINEFPDDLFSIKERQRGAVLFHIFCALYMFYALAI 123

  Fly   350 VCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNI 414
            |||:||||||:.|.|||.:::|||||||||||.|.||||.||||||::..|||:|||||||||||
Frog   124 VCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 188

  Fly   415 LFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMK 479
            |.:||:|.:|:..|:.||||.||||..:|.||:|.||.|..|..|.|||:|||..:|..|:..||
Frog   189 LCIIGVCGVFAGQVVRLTWWSLFRDSMYYIISILALIIFIYDEIIVWWESLILIVMYFFYILIMK 253

  Fly   480 WNVQVETCVKKMITKNKVTRVRSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSS 544
            :|    |.::::.|..|              |..|........| .|:|.|....:..|.|
Frog   254 YN----TKMQRLFTIKK--------------NVGNGCPVGSELQ-DGNVYSDFVCDDPSVP---- 295

  Fly   545 NAGATGNSSGGGGTSGSTQTGAKFRHGLLQLMIHTI----DPLHDGKVDEKATQLHAIASLKVLL 605
                         .....:...::.:....:|:..|    .|.:  :..|        |.|::::
Frog   296 -------------LLWKVKASQQYYNRNSVVMVDEIICSSPPKY--RFPE--------AGLRIMI 337

  Fly   606 DATKPQRGGATTSAANHVKINLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSI 670
            ....|.|  .....|:.:.||.:: .|....||...||||     |::.......:.:.
Frog   338 TNKFPPR--TRLRMASRLIINERQ-RLLHSANGTSTTTLD-----GKQELLENGGLHVD------ 388

  Fly   671 KAPEIEDEPE-----PLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSI 730
            ||.:.::|.|     |.|:  |........:....||:..::.|:|:...||.:.||.:|||.|.
Frog   389 KADDYQEENEANYLVPFSV--PSGCANIFKWAFSWPLICILYFTIPNCSKPRWENFFMLTFITST 451

  Fly   731 VWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSN 795
            :|||.|||:|||...|.|.|..||..:||:||||||||:||.:.|:||||:|.||||||:|:|||
Frog   452 LWIAIFSYIMVWMVTVIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNSIGSN 516

  Fly   796 IFDVTVGLPIPWLLYGII--YGAPVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTM 858
            :||:.|||.:||.|..:|  ||:.|::||.|:|.|:.:|...:...|..|...:|:::|..||.:
Frog   517 VFDILVGLGVPWGLQTMIINYGSTVKINSKGLVYSVILLLGSVALTVGGIYVNKWKLDKKFGFYV 581

  Fly   859 FLLYFAFVAVSLMFEYDVIT 878
            ..||..|:..|::.||:|.|
Frog   582 LFLYAIFLCFSVLIEYNVFT 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nckx30C	NP_652011.3	Na_Ca_ex	336..480	CDD:279963	90/143 (63%)
Nckx30C	NP_652011.3	Na_Ca_ex	721..871	CDD:279963	76/151 (50%)
slc24a4	XP_002933272.2	2A1904	<91..596	CDD:273344	219/566 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168500at2759
OrthoFinder	1	1.000	-	-		FOG0000196
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920