DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VhaPPA1-1 and ATP6V0B

DIOPT Version :9

Sequence 1:	NP_001247111.1	Gene:	VhaPPA1-1 / 45247	FlyBaseID:	FBgn0028662	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_001281262.1	Gene:	ATP6V0B / 533	HGNCID:	861	Length:	261	Species:	Homo sapiens

Alignment Length:	183	Identity:	119/183 - (65%)
Similarity:	143/183 - (78%)	Gaps:	7/183 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAVATILTLYFVMTGKGERVSVGWFLASSNPYMWACLGIGLSVSLSVVGAALGIHTTGTSIVGGG 82
            |||....|::.:    |.|..|.|||..::|:||:.|||||::||||||||.||:.||:||:|||
Human    20 LAVGVCYTIFDL----GFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGG 80

  Fly    83 VKAPRIKTKNLISVIFCEAVAIYGLITAIVLSGQLEQFSMETALSQAAIQNTNWFSGYLIFGAGL 147
            |||||||||||:|:||||||||||:|.|||:|...|.||   |....||.:.|:.:||.:|||||
Human    81 VKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFS---ATDPKAIGHRNYHAGYSMFGAGL 142

  Fly   148 AVGLVNLFCGIAVGIVGSGAALSDAANAALFVKILIVEIFGSAIGLFGLIVGI 200
            .|||.|||||:.||||||||||:||.|.:|||||||||||||||||||:||.|
Human   143 TVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAI 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VhaPPA1-1	NP_001247111.1	ATP-synt_Vo_c_ATP6F_rpt1	51..113	CDD:349417	48/61 (79%)
VhaPPA1-1	NP_001247111.1	ATP-synt_Vo_c_ATP6F_rpt2	138..202	CDD:349418	50/63 (79%)
ATP6V0B	NP_001281262.1	PRK08344	48..199	CDD:236246	108/151 (72%)
		ATP-synt_C	52..112	CDD:278563	48/59 (81%)
		ATP-synt_C	136..196	CDD:278563	48/60 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143520
Domainoid	1	1.000	100	1.000	Domainoid score	I7052
eggNOG	1	0.900	-	-		E1_COG0636
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2986
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3363
Isobase	1	0.950	-	0	Normalized mean entropy	S432
OMA	1	1.010	-	-		QHG53850
OrthoDB	1	1.010	-	-		D1408246at2759
OrthoFinder	1	1.000	-	-		FOG0002690
OrthoInspector	1	1.000	-	-		oto90443
orthoMCL	1	0.900	-	-		OOG6_102000
Panther	1	1.100	-	-	LDO	PTHR10263
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1637
SonicParanoid	1	1.000	-	-		X2155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750