DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capt and Cap1

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_071778.2	Gene:	Cap1 / 64185	RGDID:	620309	Length:	474	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	228/508 - (44%)
Similarity:	313/508 - (61%)	Gaps:	59/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LESICERLETLVDRLERTLTAPQPIELPTPTLPPPPAEEEEALPVFEKAETPPPPPSPPSSNMSV 362
            ::::.||||..|.||| .::....:.......|     .:.|:|.                   |
  Rat     4 MQNLVERLERAVGRLE-AVSHTSDMHCGYGDSP-----SKGAVPY-------------------V 43

  Fly   363 AGFEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVTLATQIAQPAQPKQAELLKPTS 427
            ..|:.::|.|:::||.:|.:|||||.:|||:|.:....:...:..|:|..|||..|.::||.|.|
  Rat    44 QAFDSLLANPVAEYLKMSKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPIS 108

  Fly   428 TQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPYVKEMNDAGQFYTNRVLKEWKE 492
            .||..:..||||:|.|.|||||||:||||.|||||.:...|||:|||||||..|||||||||:::
  Rat   109 EQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFVKEMNDAAMFYTNRVLKEYRD 173

  Fly   493 KDVTHVEWARAWVQTLTELQAYIRQYHTTGLVWSGKG----------AAPA-GGAPPPPPPGGLP 546
            .|..||:|.||::...|||||||:::|||||.||..|          :.|: |..|||||||  |
  Rat   174 VDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSVGSGPPPPPPG--P 236

  Fly   547 PPPPMLDLSALKLDSAGDD---RSALFAQINQGADITKGLKKVTGDMQTHKNPSL-------RTG 601
            ||||      :...|..||   |||||||||||..||..||.|:.||:|||||:|       |:|
  Rat   237 PPPP------VPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSG 295

  Fly   602 PAPFKSPAQSGGSKAVAAPSAAQAKAP-VFERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCE 665
            |.||.:|.    .:...:|..|..|.| :.|.:||||.:|.|:|.:.|::::.|:..|.|::||.
  Rat   296 PKPFSAPK----PQTSPSPKPATKKEPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCV 356

  Fly   666 GSTLTVKGKVNNIVFDSCKKCSLLFDSVVASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSK 730
            .:||.:|||:|:|..|:|||..|:||.||..||.:|.:.|::||:|.|||:||:|||||..||||
  Rat   357 NTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHAYLSK 421

  Fly   731 DSLGVEIVNSKSSEMNILLPDDSGDYTELALPEQYKTTIAGKTLKTVCVDSLG 783
            :||..|||::||||||:|:|.:.||:.|..:|||:||...|:.|.|...:..|
  Rat   422 NSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	145/325 (45%)
		CAP_C	633..781	CDD:285769	74/147 (50%)
		CARP	664..701	CDD:197827	19/36 (53%)
		CARP	702..739	CDD:197827	22/36 (61%)
Cap1	NP_071778.2	CAP_N	5..61	CDD:395969	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..252		17/44 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..316		15/42 (36%)
		CAP_C	318..472	CDD:400772	76/153 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351004
Domainoid	1	1.000	253	1.000	Domainoid score	I2000
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74572
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		otm46355
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	O	PTHR10652
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760