DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment capt and cap1

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_956203.1	Gene:	cap1 / 334527	ZFINID:	ZDB-GENE-030131-6459	Length:	463	Species:	Danio rerio

Alignment Length:	500	Identity:	252/500 - (50%)
Similarity:	322/500 - (64%)	Gaps:	54/500 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LESICERLETLVDRLERTLTAPQPIELPTPTLPPPPAEEEEALPVFEKAETPPPPPSPPSSNMSV 362
            |..:.:|||..|.|||         .:.:......||....|:.|:                  |
Zfish     4 LAGLVQRLEVAVGRLE---------SMSSSGSGGGPAAGSGAVGVY------------------V 41

  Fly   363 AGFEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVTLATQIAQPAQPKQAELLKPTS 427
            ..::.:::|||:||.|||.||||||.:|||::|.||.||.|.:..|:...:|:.|....||.|.|
Zfish    42 EAYDGLISGPLAQYFTLSQKIGGDVLKHAEMMKQAFTSQRQLLATASCSQKPSDPVLNALLAPVS 106

  Fly   428 TQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPYVKEMNDAGQFYTNRVLKEWKE 492
            ..|..:|.||||:|||||||||||:|||:||||||.:...||||||||.||..||||||||::||
Zfish   107 KAIQDVQAFREKNRSSPFFNHLSAVSESVPALGWVAMAPKPGPYVKEMQDAAMFYTNRVLKDYKE 171

  Fly   493 KDVTHVEWARAWVQTLTELQAYIRQYHTTGLVWSGKG---AAPAGGAPPPPPPGGLPPPPPMLDL 554
            ||.|||||..|:|...|||||||:|:|||||.||..|   ||..||||.|||||  |||||| ||
Zfish   172 KDKTHVEWVNAYVTIWTELQAYIKQHHTTGLSWSKTGPVAAAAGGGAPAPPPPG--PPPPPM-DL 233

  Fly   555 SALKLDSAGD----DRSALFAQINQGADITKGLKKVTGDMQTHKNPSLR-------TGPAPFKSP 608
            :.   .|.||    :|:||||.||:|:|||||||.|:.|.:|||||.||       :||.|| :|
Zfish   234 NK---SSGGDSEPTNRNALFASINKGSDITKGLKHVSDDQKTHKNPGLRGQTGPSVSGPKPF-TP 294

  Fly   609 AQSGGSKAVAAPSAAQAKAPVFERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCEGSTLTVKG 673
                  :..|..|.|::..||.|.|||||.:|.|:....|::.:.|:..|||.|||..|||.|||
Zfish   295 ------RPTATASPARSLPPVLELDGKKWKVENQEGAQNLVISDTELKQVVYGFKCNNSTLQVKG 353

  Fly   674 KVNNIVFDSCKKCSLLFDSVVASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSKDSLGVEIV 738
            |:|:|..|:|||..|:||.||..||.:||:.|::||:|.|||:||:|||||.:|||||||..|||
Zfish   354 KINSITLDNCKKMGLVFDDVVGIVEVINCRDVKIQVIGKVPTISINKTDGCHVYLSKDSLSCEIV 418

  Fly   739 NSKSSEMNILLPDDSGDYTELALPEQYKTTIAGKTLKTVCVDSLG 783
            ::||||||:|:|:..|::||:.:|||:||...|..|.|...:..|
Zfish   419 SAKSSEMNVLVPNKDGEFTEIPVPEQFKTVWDGSKLVTTATEIAG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	161/318 (51%)
		CAP_C	633..781	CDD:285769	80/147 (54%)
		CARP	664..701	CDD:197827	21/36 (58%)
		CARP	702..739	CDD:197827	24/36 (67%)
cap1	NP_956203.1	CAP_N	5..285	CDD:279545	159/312 (51%)
		CAP_C	312..461	CDD:285769	80/148 (54%)
		CARP	344..381	CDD:197827	21/36 (58%)
		CARP	382..419	CDD:197827	24/36 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592721
Domainoid	1	1.000	289	1.000	Domainoid score	I1518
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74572
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1502
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		otm25988
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	O	PTHR10652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R167
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790