DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capt and cap1

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_587817.1	Gene:	cap1 / 2538829	PomBaseID:	SPCC306.09c	Length:	551	Species:	Schizosaccharomyces pombe

Alignment Length:	533	Identity:	186/533 - (34%)
Similarity:	282/533 - (52%)	Gaps:	68/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 SICERLETLVDRLERTLTA---PQP-----------------IELPTPTLPP----PPA----EE 336
            :|.:|||....|||..:.:   |.|                 ..:.|||.|.    .||    .:
pombe    16 TILKRLEAATSRLEDLVESGHKPLPNMHRPSRDSNSQTHNISFNIGTPTAPTVSTGSPAVASLHD 80

  Fly   337 EEALPVFEKAETPPPPPSPPSSNMSVAGFEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQ 401
            :.|..:..:..:.....:..:...|::.:::..:..||:|:.||.||||.:|:.:|.|:.||...
pombe    81 QVAAAISPRNRSLTSTSAVEAVPASISAYDEFCSKYLSKYMELSKKIGGLIAEQSEHVEKAFNLL 145

  Fly   402 LQYVTLATQIAQP--AQPKQAELLKPTSTQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCV 464
            .|.:::|.:..:|  ..|:..|.|||..:::..|.:.|::||::|.||.||.:...|..||||.|
pombe   146 RQVLSVALKAQKPDMDSPELLEFLKPIQSELLTITNIRDEHRTAPEFNQLSTVMSGISILGWVTV 210

  Fly   465 EKTPGPYVKEMNDAGQFYTNRVLKEWKEKDVTHVEWARAWVQTLTELQAYIRQYHTTGLVWSGK- 528
            |.||..::.||.|:.|||.|||:||:|.||...:||.|:::..||||..|::.:..|||.||.|
pombe   211 EPTPLSFMSEMKDSSQFYANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFKTGLTWSTKQ 275

  Fly   529 ----------------------GAAPAGGAPPPPPPGGLPPPPPMLDL-----SALKLDSAGDDR 566
                                  |.:..||.||||     |||||..|.     .....|:.| |.
pombe   276 DAVPLKTALANLSASKTQAPSSGDSANGGLPPPP-----PPPPPSNDFWKDSNEPAPADNKG-DM 334

  Fly   567 SALFAQINQGADITKGLKKVTGDMQTHKNPSLR-TGPAPFKSPAQSGGSKAVAAPS-AAQAKAPV 629
            .|:||:||:|..||.||:||.....|||||:|| |||.|  .|.....|.|.:.|: .|..|.|.
pombe   335 GAVFAEINKGEGITSGLRKVDKSEMTHKNPNLRKTGPTP--GPKPKIKSSAPSKPAETAPVKPPR 397

  Fly   630 FERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCEGSTLTVKGKVNNIVFDSCKKCSLLFDSVV 694
            .|.:..||.:|.|.:|..:::::.|:|:.|.:|.|...|:.:|||:|.:...:||:.|::.|::|
pombe   398 IELENTKWFVENQVDNHSIVLDSVELNHSVQIFGCSNCTIIIKGKLNTVSMSNCKRTSVVVDTLV 462

  Fly   695 ASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSKDSLGVEIVNSKSSEMNILLPDDSGDYTEL 759
            |:.:...|.:...||:..||.:.||:.||..:||||.||..|:|.|||:.:||.:|::.|||.|.
pombe   463 AAFDIAKCSNFGCQVMNHVPMIVIDQCDGGSIYLSKSSLSSEVVTSKSTSLNINVPNEEGDYAER 527

  Fly   760 ALPEQYKTTIAGK 772
            |:|||.|..:..|
pombe   528 AVPEQIKHKVNEK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	123/362 (34%)
		CAP_C	633..781	CDD:285769	54/140 (39%)
		CARP	664..701	CDD:197827	12/36 (33%)
		CARP	702..739	CDD:197827	16/36 (44%)
cap1	NP_587817.1	CAP_N	15..373	CDD:279545	123/362 (34%)
		CAP_C	400..550	CDD:285769	54/141 (38%)
		CARP	432..467	CDD:197827	12/34 (35%)
		CARP	470..507	CDD:197827	16/36 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	188	1.000	Domainoid score	I753
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74572
Inparanoid	1	1.050	309	1.000	Inparanoid score	I581
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		oto102074
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	LDO	PTHR10652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R167
SonicParanoid	1	1.000	-	-		X1462
TreeFam	1	0.960	-	-
	13	12.850