DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capt and cas-1

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001360035.1	Gene:	cas-1 / 181729	WormBaseID:	WBGene00000294	Length:	1195	Species:	Caenorhabditis elegans

Alignment Length:	925	Identity:	287/925 - (31%)
Similarity:	407/925 - (44%)	Gaps:	229/925 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKAGKKEKEKRNAEEENGGQVTEKEEP----QLNGKPGTPKEEPEPVK--PEKELLEAHNPEDVP 67
            |:......|:.|....:..:.|: |:|    |.:......:.:|.||:  |.....:..||...|
Worm   345 PRGNSLVSEQPNFRSYHNDEPTQ-EQPNPRYQRSSSNFMQQRDPSPVRSPPIISYAQQSNPFSFP 408

  Fly    68 T------------STQPNTA--QPTQAEAASKSSPAN-----PALAP---KEPE-PLARSTHSST 109
            .            |::.:|.  |..:...|.|.:..|     ||.|.   :|.| |.::...|:.
Worm   409 NPINQVNYNQEDHSSRVSTGGYQDRRVAQAPKEATTNVYQNVPAAAAVNFREKERPTSQYLESNR 473

  Fly   110 STA----PPASMTSGDAEEADEVVVVAT-----------VTPTTPP-PQPPPTKSCLSRHNSTHQ 158
            ::|    .|..:|:      |.|:.:..           ..|..|. |||             ||
Worm   474 NSAAFPNEPIKLTN------DRVLRIHPHQQVQDQYHHHQMPEEPHYPQP-------------HQ 519

  Fly   159 SIKKKVNISNRAEIIEP--------------DPLPLLLLASQNQGSLLD------DDEVFSDSLP 203
            .|::    |.||.|..|              .|.|.....:|||....:      :.:||:.|.|
Worm   520 PIQQ----SQRARIQSPLRDFARLTSPIREVAPQPYHPPQAQNQNQNPERIFSPVESKVFNRSGP 580

  Fly   204 PPKRESMCAPYIEGDVVSETLFFAHGLPSWFDDERLNDIGCIEPPVTPVGRDELELKRQRLYTEL 268
                     ..|.|...:...:.:|  ...||.....|..  :|||
Worm   581 ---------TVINGFTSNRHTYNSH--TDDFDSRNRRDSS--QPPV------------------- 613

  Fly   269 LRAAHAAVEHSVAVR---DNEPEAKPSAAVDHLESICERLETLVDRLERTLTAPQPIELPTPTLP 330
                 |.:|.::.|.   |..|..||.....|..|   .....|..::.|.....|...||.|..
Worm   614 -----AIIEPNINVHMPSDPMPYNKPHFGHGHGHS---NGNNNVHSVKPTSHYSNPTFSPTSTFS 670

  Fly   331 PP---PAEEEEALPVFEKAETPPP---------------------------PPSPPSSNMSV--- 362
            |.   ..:.:..|.:.|.|....|                           |....||:..|
Worm   671 PNSNYDNDNDSDLDIEEMARRALPRYLRDNEKTGRHRNLYGDNLHGILIKNPSLHRSSSKKVVFI 735

  Fly   363 ----------AG-----------FEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVT 406
                      ||           ::|.:..||:.:..|:.::|||:|.....|.:.|.|...|:.
Worm   736 DQNKASAAASAGDSGEVPAHVRAYDDAIEEPLANWSKLTDQLGGDLAAVKPKVLAMFASMRNYLW 800

  Fly   407 LATQIAQPAQPKQAELLKPTSTQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPY 471
            .|...::|:..:..::|.|....:..|.:|::..|.:|.:|||::::|::||||||.|:|||.||
Worm   801 SAAGKSEPSAEEAQKMLTPVINLLGEINNFKDTKRKTPHWNHLNSVAEALPALGWVTVKKTPAPY 865

  Fly   472 VKEMNDAGQFYTNRVLKEWKEKDVTHVEWARAWVQTLTELQAYIRQYHTTGLVW-SGKGAAP--- 532
            |||..:|.|||.|.:|:|:||.|..||||.:||.....|:|.::||.||||||| |..||||
Worm   866 VKEFIEAAQFYINPILREFKETDPRHVEWTKAWKAVFEEMQKFVRQVHTTGLVWNSAPGAAPDAS 930

  Fly   533 -----------------AGGAPPPPPPGGLPP--------PPPMLDLSALKLDSAGDDRSALFAQ 572
                             .||.||||||   ||        |||        :|:....|.||||.
Worm   931 ASAPSAAAPSAPKAPAGPGGPPPPPPP---PPADFFANIAPPP--------VDADKASRDALFAS 984

  Fly   573 INQGADITKGLKKVTGDMQTHKNPSLRTGPAPFKSPAQSGGSKAVAAPSAAQAKAPVFE-RDGKK 636
            :|||..:|..|||||.||||||||:|| |.|...:...|.|..:.|.|:|...|.|..| .:||:
Worm   985 LNQGEGVTSRLKKVTADMQTHKNPNLR-GTAVVPAAGASQGGSSPAKPAAPVRKPPHKELENGKQ 1048

  Fly   637 WIIEYQKNNTGLLVENAEMNNVVYVFKCEGSTLTVKGKVNNIVFDSCKKCSLLFDSVVASVEFVN 701
            ||:||..|:..::::.|:....||:::||.|.:.|.||.|:|..|.|||.|::||::||..|.||
Worm  1049 WIVEYFVNDPNIVLDVADKKQTVYIYRCENSVIKVNGKANSITLDGCKKTSVVFDALVAQCETVN 1113

  Fly   702 CQSVQMQVLGSVPTVSIDKTDGCQMYLSKDSLGVEIVNSKSSEMNI-LLPDDSGDYTELALPEQY 765
            |||||:|.||.:||:||.||||||:||||.:.|.|||.|||||||| :..:|.|||:|..:|||:
Worm  1114 CQSVQIQTLGELPTLSIQKTDGCQVYLSKVAQGCEIVTSKSSEMNISVQTNDDGDYSEFPVPEQF 1178

  Fly   766 KTTIAGKTLKTVCVD 780
            |||.....|.||..|
Worm  1179 KTTFVNGKLVTVVSD 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	128/387 (33%)
		CAP_C	633..781	CDD:285769	79/149 (53%)
		CARP	664..701	CDD:197827	18/36 (50%)
		CARP	702..739	CDD:197827	25/36 (69%)
cas-1	NP_001360035.1	PRK10263	<481..>570	CDD:236669	22/111 (20%)
		CAP_N	748..1017	CDD:366517	111/280 (40%)
		CAP_C	1037..1194	CDD:369992	82/157 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165247
Domainoid	1	1.000	211	1.000	Domainoid score	I1638
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74572
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		oto18659
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	LDO	PTHR10652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R167
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880