DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capt and Cap2

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_446326.1	Gene:	Cap2 / 116653	RGDID:	620310	Length:	477	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	221/492 - (44%)
Similarity:	302/492 - (61%)	Gaps:	44/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 ICERLETLVDRLERTLTAPQPIELPTPTLPPPPAEEEEALPVFEKAETPPPPPSPPSSNMSVAGF 365
            :.:|||..|.||||..:.          |..||....|...:......|           ||..|
  Rat     7 LMQRLEFAVSRLERLSSG----------LHEPPGGCGEVNSLSRGIVAP-----------SVEAF 50

  Fly   366 EDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVTLATQIAQPAQPKQAELLKPTSTQI 430
            :.::...::::|..|..:.|||..|||:|..||.:|..::.:.:|..||.:.:.|.||||.|.:|
  Rat    51 DKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQHQQPQENEVAVLLKPISEKI 115

  Fly   431 SAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPYVKEMNDAGQFYTNRVLKEWKEKDV 495
            ..||.|||::|.|..||||||:||||.||||:.|...|||||||||||..|||||||:::|..|:
  Rat   116 QEIQTFRERNRGSDMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDL 180

  Fly   496 THVEWARAWVQTLTELQAYIRQYHTTGLVWSGKG--AAPAG---------GAPPPPPPGGLPPPP 549
            .||:|.|::::..:||||||:::|||||.||..|  |:.|.         |.||||||...|.||
  Rat   181 RHVDWVRSYLKIWSELQAYIKEHHTTGLTWSKTGPVASTASAFSILSSGPGLPPPPPPPPPPGPP 245

  Fly   550 PMLDLSALKLDSAGDDRSALFAQINQGADITKGLKKVTGDMQTHKNPSLRT-----GPAPFKSPA 609
            |..:....| :.....|||||||:|||..|||||:.||.|.:.:||||||.     .|...::|:
  Rat   246 PPFENEGGK-EEPSPSRSALFAQLNQGEAITKGLRHVTDDKKIYKNPSLRAQGQIRSPTKTRTPS 309

  Fly   610 QSGGSKAVAAPSAAQAKAPVFERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCEGSTLTVKGK 674
            .: .||:    ::.|..|||.|.:||||.:|||::...|::...|:..|.|:|||:.|||.:|||
  Rat   310 PT-SSKS----NSPQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGK 369

  Fly   675 VNNIVFDSCKKCSLLFDSVVASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSKDSLGVEIVN 739
            ||:|..|:|||..|:||.||..||.:|.:.:|:||:|.|||:||:||:||.:|||||:|..|||:
  Rat   370 VNSITVDNCKKFGLVFDHVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHLYLSKDALDCEIVS 434

  Fly   740 SKSSEMNILLPDDSGDYTELALPEQYKTTIAGKTLKT 776
            :||||||:|:| ...||.|..:|||:||...|..|.|
  Rat   435 AKSSEMNVLVP-QGDDYREFPIPEQFKTIWDGSKLIT 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	137/318 (43%)
		CAP_C	633..781	CDD:285769	76/144 (53%)
		CARP	664..701	CDD:197827	21/36 (58%)
		CARP	702..739	CDD:197827	21/36 (58%)
Cap2	NP_446326.1	CAP_N	7..65	CDD:395969	17/78 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..262		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..324		20/54 (37%)
		CAP_C	323..475	CDD:400772	79/149 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351005
Domainoid	1	1.000	253	1.000	Domainoid score	I2000
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		otm46355
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	LDO	PTHR10652
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800