DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capt and CAP2

DIOPT Version :9

Sequence 1:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_006357.1	Gene:	CAP2 / 10486	HGNCID:	20039	Length:	477	Species:	Homo sapiens

Alignment Length:	500	Identity:	229/500 - (45%)
Similarity:	310/500 - (62%)	Gaps:	52/500 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 HLESICERLETLVDRLERTLTAPQPIELPTPTLPPPPAEEEEALPVFEKAETPPPPPSPPSSNMS 361
            :::.:.||||..|.|||..                             .||:..||.:....|..
Human     3 NMQGLVERLERAVSRLESL-----------------------------SAESHRPPGNCGEVNGV 38

  Fly   362 VAG-------FEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVTLATQIAQPAQPKQ 419
            :||       |:.::...::::|..|..:.|||..|||:|.|||.:|..::.:|:|..||.:...
Human    39 IAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDV 103

  Fly   420 AELLKPTSTQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPYVKEMNDAGQFYTN 484
            |.||||.|.:|..||.|||::|.|..||||||:|||||||||:.|...|||||||||||..||||
Human   104 AALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTN 168

  Fly   485 RVLKEWKEKDVTHVEWARAWVQTLTELQAYIRQYHTTGLVWSGKG-----------AAPAGGAPP 538
            ||||::|..|:.||:|.::::...:||||||:::|||||.||..|           .:...|.||
Human   169 RVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPP 233

  Fly   539 PPPPGGLPPP-PPMLDLSALKLDSAGDDRSALFAQINQGADITKGLKKVTGDMQTHKNPSLRTGP 602
            ||||  |||| ||.|..:..|.:.:...|||||||:|||..|||||:.||.|.:|:||||||...
Human   234 PPPP--LPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQG 296

  Fly   603 APFKSPAQSGGSKAVAAPS-AAQAKAPVFERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCEG 666
            ...:||.:|......:..| .:|..|||.|.:||||.:|||::...|::...|:..|.|:||||.
Human   297 GQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEK 361

  Fly   667 STLTVKGKVNNIVFDSCKKCSLLFDSVVASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSKD 731
            ||:.:|||||:|:.|:|||..|:||:||..||.:|.|.:|:||:|.|||:||:||:||.:|||:|
Human   362 STIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSED 426

  Fly   732 SLGVEIVNSKSSEMNILLPDDSGDYTELALPEQYKTTIAGKTLKT 776
            :|..|||::||||||||:|.| |||.|..:|||:||...|..|.|
Human   427 ALDCEIVSAKSSEMNILIPQD-GDYREFPIPEQFKTAWDGSKLIT 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	141/323 (44%)
		CAP_C	633..781	CDD:285769	78/143 (55%)
		CARP	664..701	CDD:197827	21/36 (58%)
		CARP	702..739	CDD:197827	21/36 (58%)
CAP2	NP_006357.1	CAP_N	7..297	CDD:307392	141/320 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..261		15/37 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..321		20/47 (43%)
		CAP_C	327..475	CDD:312200	78/144 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157046
Domainoid	1	1.000	256	1.000	Domainoid score	I2044
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1748
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		otm42204
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	LDO	PTHR10652
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760