Protein Alignment COX1 and COX1

DIOPT Version :10

• Sequence 1: YP_003024028.1
• Gene: COX1 / 4512
• HGNCID: 7419
• Length: 513
• Species: Homo sapiens
• Sequence 2: NP_009305.1
• Gene: COX1 / 854598
• SGDID: S000007260
• Length: 534
• Species: Saccharomyces cerevisiae
• Alignment Length: 528
• Identity: 301/528 - (57%)
• Similarity: 398/528 - (75%)
• Gaps: 25/528 - (4%)

Human     5 RWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGN--LLGNDHIYNVIVTAHAFVMIF 67
            |||:|||.|||..||.:...::|:.|||:||:||.||..||:  |.||..::||:|..||.:|||
Yeast     4 RWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIF 68

Human    68 FMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPL 132
            |:|||.:||||||:|:||||||.|.||||:||::||:||..|:.|:.|.:||:||||||||||||
Yeast    69 FLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPL 133

Human   133 AGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLL 197
            :...:|.|.||||.||:|||..:||:|||||||.|.:||:...||.::.||||||:.|||.||||
Yeast   134 SSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLL 198

Human   198 SLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYS 262
            |||||:|||||||.|||.||:||:.:||||||||:|||||||||||||||:||||:|||:|:.||
Yeast   199 SLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYS 263

Human   263 GKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATL 327
             ||..||.:.||:||.|||.|||:||:|||:.||:|.||||||||||||||||||:|:||||||:
Yeast   264 -KKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLATI 327

Human   328 HGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG 392
            ||.:::.:..:|:|:.|:||||:|||||:.|||:|||:..|||||||.||||||||||:|::..|
Yeast   328 HGGSIRLATPMLYAIAFLFLFTMGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAG 392

Human   393 FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVG 457
            :.:|.|...|...::..|:|.|.::|||.|:.|||.||||::|||||..|||||:..||.::|:|
Yeast   393 YYYWSPQILGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASIG 457

Human   458 SFISLTAVMLMIFMIWEAF-------ASKRKVLMVEEP---------------SMNLEWLYGCPP 500
            |||:..::.|.|:::::..       .:.:.|:..:.|               |.::|:|...||
Yeast   458 SFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVESNTIFNLNTVKSSSIEFLLTSPP 522

Human   501 PYHTFEEP 508
            ..|:|..|
Yeast   523 AVHSFNTP 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_003024028.1	COX1	5..507	CDD:177210	300/525 (57%)
COX1	NP_009305.1	Cyt_c_Oxidase_I	9..488	CDD:238833	289/502 (58%)