Protein Alignment Nsun2 and NCL1

DIOPT Version :10

• Sequence 1: NP_652007.1
• Gene: Nsun2 / 45064
• FlyBaseID: FBgn0026079
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_009529.1
• Gene: NCL1 / 852257
• SGDID: S000000120
• Length: 684
• Species: Saccharomyces cerevisiae
• Alignment Length: 757
• Identity: 256/757 - (33%)
• Similarity: 392/757 - (51%)
• Gaps: 93/757 - (12%)

  Fly     5 QKQNFFAARKRQKRENGPKRTDRQAQPYEEIKRDNAFFIKYYQLQKICATDEEWTQFLASIRDNL 69
            :::||   :|..|:..|.:...|..:.:.|:.::|..:.|||:...:...| :|.:|..:.:..|
Yeast     3 RRKNF---KKGNKKTFGARDDSRAQKNWSELVKENEKWEKYYKTLALFPED-QWEEFKKTCQAPL 63

  Fly    70 PTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNGLAYQLHLTRK 134
            |.|||:||.:..|..:|::.:.:..........|     .|.::.|:.|||||:.||:||.:.:.
Yeast    64 PLTFRITGSRKHAGEVLNLFKERHLPNLTNVEFE-----GEKIKAPVELPWYPDHLAWQLDVPKT 123

  Fly   135 DIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGSKTAQLIEALH 199
            .||::|...:...||:||...|.|||||||||||||||:|:|...||||||||||||||||||||
Yeast   124 VIRKNEQFAKTQRFLVVENAVGNISRQEAVSMIPPIVLEVKPHHTVLDMCAAPGSKTAQLIEALH 188

  Fly   200 AAPEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNL-VTTKPDGSKAILK 263
            ...:|   |.|||:|||.|..|.:|||||.|||||..|:|.|||:..||.: :....:....:||
Yeast   189 KDTDE---PSGFVVANDADARRSHMLVHQLKRLNSANLMVVNHDAQFFPRIRLHGNSNNKNDVLK 250

  Fly   264 FDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGGRLVYSTCSLNPI 328
            ||:||||||||||||:|||.::|..||......||.:|..|:.||..:|:..|||||||||||||
Yeast   251 FDRILCDVPCSGDGTMRKNVNVWKDWNTQAGLGLHAVQLNILNRGLHLLKNNGRLVYSTCSLNPI 315

  Fly   329 ENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFEEVPESLHTIIRP 393
            |||||:...::.....:.||:....:|||....|::.|.:..:.:.: .|:.:|  .:|.:...|
Yeast   316 ENEAVVAEALRKWGDKIRLVNCDDKLPGLIRSKGVSKWPVYDRNLTE-KTKGDE--GTLDSFFSP 377

  Fly   394 GMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVELVKLNETAKQPAAE 458
            .     .:|.:|..|:.|:||.||.|::||||:.|.||       ..|..|..    |.|..:..
Yeast   378 S-----EEEASKFNLQNCMRVYPHQQNTGGFFITVFEK-------VEDSTEAA----TEKLSSET 426

  Fly   459 PQVDADG---KPIEEKSVPWGPQRKKRRLHGYKEDPYVFFGENDPDYQAIK---EFYQLDESLSQ 517
            |.::::|   |.|:.:.|    |:|:|......|:|:||.   ||.::|:|   :||.:|....:
Yeast   427 PALESEGPQTKKIKVEEV----QKKERLPRDANEEPFVFV---DPQHEALKVCWDFYGIDNIFDR 484

  Fly   518 R-CLLTRCVTEKKKNIYYCSEPIRDLVLNNENNIKIINTGVKTFVRCENRHTVH-PFRLAQEGLQ 580
            . ||:.....|..:.:|.....::|::..|::.:|||.:|||.||  ..|..:. .:|:..|.|.
Yeast   485 NTCLVRNATGEPTRVVYTVCPALKDVIQANDDRLKIIYSGVKLFV--SQRSDIECSWRIQSESLP 547

  Fly   581 TSNAFMGASRRIQVEREDLVMMLNCTDPT-QPPSTHELKKETQERCKELGVGSCILKYVD----- 639
            .....|.::|.::...|.|..:|..:.|. ....:..:..:..|:..:|..|..   ::|
Yeast   548 IMKHHMKSNRIVEANLEMLKHLLIESFPNFDDIRSKNIDNDFVEKMTKLSSGCA---FIDVSRND 609

  Fly   640 -QRFTLYTVGWRGTSSLRAYVQKDETIHIL-RLLGADLSKFETNKYEDARVAAAAAADAEVGKSA 702
             .:..|:...|:|...:...|.|::|..:| |:.|.|                   |:|:...||
Yeast   610 PAKENLFLPVWKGNKCINLMVCKEDTHELLYRIFGID-------------------ANAKATPSA 655

  Fly   703 EAEADSSGDGDATESTFSGSGAIDVTVAAETTGTPMDTEVVA 744
            |   :...:.:.|||.           |..||||..:....|
Yeast   656 E---EKEKEKETTESP-----------AETTTGTSTEAPSAA 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_652007.1	RsmB	<55..433	CDD:439914	170/378 (45%)
NCL1	NP_009529.1	RsmB	<44..412	CDD:439914	170/391 (43%)