DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun2 and NSUN7

DIOPT Version :9

Sequence 1:	NP_652007.1	Gene:	Nsun2 / 45064	FlyBaseID:	FBgn0026079	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_078953.4	Gene:	NSUN7 / 79730	HGNCID:	25857	Length:	718	Species:	Homo sapiens

Alignment Length:	716	Identity:	132/716 - (18%)
Similarity:	235/716 - (32%)	Gaps:	250/716 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KRENGPKR--TDRQAQPYEEIKRDNAF-FIKYYQLQKICATDEEWTQFLASIRDNLPTTFRVTGF 78
            |..|.|.|  ::.:.|.::.:..:.|| .:||..:.:....|.              ..|..|..
Human    69 KYGNEPLRSLSESEDQSFQRLSYELAFSALKYQDILETILIDS--------------CIFPSTTI 119

  Fly    79 KDEAKALLSII---------ETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNGLAYQL----- 129
            .|...:|:.::         :|::.::....::|:     ::||..|      |....:|
Human   120 PDHLSSLIIVMLYDFQDRKFQTRVLSDNEEPISEV-----QEVENLL------NSFKIKLAAALA 173

  Fly   130 ------------HLTRKDIRRSE------PLYRLHNFLIV--ETTAGGISRQEAVSMIPPIVLDV 174
                        |:..:.:|:.|      |||...|...:  |.....:.|:....:...:.:|
Human   174 RCRIKHDALSIYHILPETVRKQELRASTLPLYAWINTCKISPEEVYNNLKRRGYNKVKSVLHID- 237

  Fly   175 RPTDKVL-------DMCAAPGSKTAQLIE------------------ALHAAPEEHKIPPGFVLA 214
               |||.       |:...|......||.                  |:|:......:....::.
Human   238 ---DKVFAVDQHCYDVLIFPSHLKNDLINIDLFKDYKLIFQDKSRSLAVHSVKALLNMDDDVLMV 299

  Fly   215 NDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVF----------PNLVT--TKPDGSKAI------ 261
            |   ....|.:.|.:       :|..|:.|.||          |:|.|  || .|.|.|
Human   300 N---TGSWYTVSHMS-------ILTNNNTSKVFVCGVQSQAKDPDLKTLFTK-IGCKNIEILHEK 353

  Fly   262 ----------LKFDKILCDVP-CSGDGT-------LRKNPDIWLKWNLAQ----AYNLHGI---Q 301
                      |:..|::..:| |||.|.       |.::.|.....:.:|    ...||.:   |
Human   354 FINIESKDHRLQKVKVILLLPRCSGLGVSNPVEFILNEHEDTEFLKDHSQGGISVDKLHVLAQQQ 418

  Fly   302 YRIVRRGAEMLEVGGRLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDW 366
            |..:....:..:... :||.|||:.|.|||||:::       |||..|.|:  .|..|:
Human   419 YEQLTHAMKFTKAQA-VVYCTCSVFPEENEAVVKK-------ALEFQDLGN--KGQPYR------ 467

  Fly   367 KLATKEVDQIFTRFEEVPESLHTIIRPGMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEK 431
                                    :.|.:.||.:.:..::..:|..|:.|. :.:.|.|:::|.:
Human   468 ------------------------LSPPVLPLCSLKEIQLSTDKFFRMEPS-EITNGCFLSILTR 507

  Fly   432 RRQLSFEKNDVVELVKLNETAKQPAAEPQVDADGKPIEEKSVPWGPQRKKRRLHGYKEDPYVFFG 496
            .|       |..|.|.:|:...:.||:..:|         .:..|...|:.:.....:.......
Human   508 ER-------DPSETVSVNDVLARAAAKGLLD---------GIELGKSSKREKKKKKSKTSLTKGA 556

  Fly   497 ENDPDYQ-AIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVLNNENNIKIINTGVKTF 560
            ..|...| .|.||...:             |:...|:   ||.:....|..:|..::   |..:.
Human   557 TTDNGIQMKIAEFLNRE-------------TKASANL---SETVTKPPLPQKNTAQV---GASSQ 602

  Fly   561 VRCENRHTVHPFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCTDPTQP--PSTHELKKETQE 623
            .|..|:...||         ...||                 :..|.|::|  ..||.|:...::
Human   603 TRKPNKLAPHP---------AVPAF-----------------VKNTCPSRPRERQTHFLRPRPED 641

  Fly   624 R 624
            |
Human   642 R 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_652007.1	RsmB	13..433	CDD:223222	97/520 (19%)
NSUN7	NP_078953.4	Methyltr_RsmF_N	131..509	CDD:330305	83/444 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..557		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..616		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810