DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun2 and nsun2

DIOPT Version :9

Sequence 1:	NP_652007.1	Gene:	Nsun2 / 45064	FlyBaseID:	FBgn0026079	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001015962.1	Gene:	nsun2 / 548716	XenbaseID:	XB-GENE-962623	Length:	798	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	333/808 - (41%)
Similarity:	467/808 - (57%)	Gaps:	91/808 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRNQKQNFFAARKRQKR--------ENGPKRTDRQAQPYE----EIKRDNAFFIKYYQLQKICA 53
            |||..::|    |:|.:|        |...:|..|:...:|    ||.::|..|..|||..|| .
Frog     1 MGRRNRRN----RQRHQRSTEQRSPAEEEQRRKAREQAAWECGYPEIIKENKLFEHYYQELKI-V 60

  Fly    54 TDEEWTQFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCL 118
            .|.||.:|:||:|:.||.|.|:||:|..||.:|..::.:.|.| ::.:....||    :|.|..|
Frog    61 PDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKE-LQDIEVDGQK----IEAPQPL 120

  Fly   119 PWYPNGLAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDM 183
            .|||..||:..:|:||.||:|..|.:.|.||:.||.:|.||||||||||||::|.|:|..|:|||
Frog   121 SWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDM 185

  Fly   184 CAAPGSKTAQLIEALHA---APEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSS 245
            ||||||||||:||.|||   .|    .|.|||:||||||.|||:||||||||||||::|.|||:|
Frog   186 CAAPGSKTAQIIEMLHADMNVP----FPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDAS 246

  Fly   246 VFPNLVTTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAE 310
            ..|.|: .:.:||:.:|.:|:||||||||||||||||.|:|.||....:..|||:|.||..||.|
Frog   247 SIPRLL-VENNGSREVLYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVE 310

  Fly   311 MLEVGGRLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQ 375
            .|..|||:|||||||||:|:|||:..::..::|:|||.|....:||||:.||:|.||:.||| ..
Frog   311 QLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKE-GH 374

  Fly   376 IFTRFEEVPESLHTIIRPGMFPLPADE--MAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFE 438
            .:.::|::|.|.||.|||.||| |.||  :..:.|.:|:|:|||.|::||||||||.|:..:.:.
Frog   375 WYEKWEDIPTSRHTQIRPTMFP-PKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWN 438

  Fly   439 KND------------------VVELVK-LNETAKQPAAEPQVDADG---KPIEEKS-------VP 474
            |..                  ..|||| :.|.:...|.||.||.:.   ||...:|       |.
Frog   439 KRQPKLQRRPPVSACDASIAVAPELVKAVTENSAGMADEPAVDTENGETKPCTNQSDSSKTDIVC 503

  Fly   475 WGPQRKKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPI 539
            ..|..||.:|.|:||||:||..|:||.:..|:.||.||.|..::.||||....||:.:|..|:.:
Frog   504 CPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKEL 568

  Fly   540 RDLVLNNENNIKIINTGVKTFVRCENRHTVH---PFRLAQEGLQTSNAFMGASRRIQVEREDLVM 601
            |:::|:|...:|:||||:|  |.|.|.....   .:||||||:.|...|:.| |.:.|..||:.:
Frog   569 RNVLLHNSEKMKVINTGIK--VLCRNNDGEQYGCAYRLAQEGIYTLYPFINA-RIVTVSIEDIKV 630

  Fly   602 MLNCTDPTQPPSTHELKKETQERCKELGVGSCILKYVDQ-------RFTLYTVGWRGTSSLRAYV 659
            :|.    .:.|...:..||||::.....:||.:|||...       :..:...||||.:|:|::|
Frog   631 LLT----QENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETLQCPIVLCGWRGKTSIRSFV 691

  Fly   660 QKDETIHILRLLGADLSKFETNKYEDARVAAAAAADAEVG----------KSAEAEADSSGDG-D 713
            .|:|.:|.||::|.::.|.:....|...|...|..:..:.          :|.|...:.|||. |
Frog   692 PKNERLHYLRMMGVEVFKEKAEVLEKKPVEGKACDEEHIDEKMDIDGAKEESKELSGNESGDDED 756

  Fly   714 ATESTFSGSGAIDVTVAAETTGTPMDTE 741
            ..|......|.::......|:..|...|
Frog   757 PKEEDVIDRGVLEHVALKNTSAIPASVE 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_652007.1	RsmB	13..433	CDD:223222	222/436 (51%)
nsun2	NP_001015962.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		9/32 (28%)
		RsmB	19..432	CDD:223222	218/425 (51%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	186..192		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..499		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..798		12/62 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I1310
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9817
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1084
OMA	1	1.010	-	-		QHG54313
OrthoDB	1	1.010	-	-		D291505at33208
OrthoFinder	1	1.000	-	-		FOG0002888
OrthoInspector	1	1.000	-	-		oto103693
Panther	1	1.100	-	-	LDO	PTHR22808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6576
SonicParanoid	1	1.000	-	-		X2247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110