DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun2 and NOP2

DIOPT Version :9

Sequence 1:	NP_652007.1	Gene:	Nsun2 / 45064	FlyBaseID:	FBgn0026079	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001245238.1	Gene:	NOP2 / 4839	HGNCID:	7867	Length:	845	Species:	Homo sapiens

Alignment Length:	502	Identity:	121/502 - (24%)
Similarity:	194/502 - (38%)	Gaps:	137/502 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KRENGPKRTDRQAQPYEEIKRDNAFFIKY--YQLQKICATD----EEWTQFLASIRDNLPTTFRV 75
            :||.|..|::.    ...:|:|.|.:..|  :.|.|:  .|    .|..:||.:.....|.|.|.
Human   289 QREEGRSRSEY----LNRLKKDLAIYYSYGDFLLGKL--MDLFPLSELVEFLEANEVPRPVTLRT 347

  Fly    76 TGFK----DEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNGL-AYQLHLTRKD 135
            ...|    |.|:||::           |.|         ::: ||. .|...|| .|.
Human   348 NTLKTRRRDLAQALIN-----------RGV---------NLD-PLG-KWSKTGLVVYD------- 383

  Fly   136 IRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGSKTAQLIEALHA 200
              .|.|:.....:|     ||....|.|.||:|.:.|..:..:::||||.|||.||:.:.:.:..
Human   384 --SSVPIGATPEYL-----AGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKN 441

  Fly   201 APEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLVTTKPDGSKAILKFD 265
            .        |.:||||.:..|...:|....||.....:::::|...||          |.:..||
Human   442 T--------GVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFP----------KVVGGFD 488

  Fly   266 KILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEML----EVGGRLVYSTCSLN 326
            ::|.|.||||.|.:.|:|.:....:.........:|..::....:.:    :.||.|||.|||:.
Human   489 RVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSIT 553

  Fly   327 PIENEAVLQRIIKDADGALELVDAGHLVP-GLKYKPGMTDWKLATKEVDQIFTRFEEVPESLHTI 390
            ..|||.|:...:|..:        ..||| ||.:.             .:.||||.|  ...|..
Human   554 VEENEWVVDYALKKRN--------VRLVPTGLDFG-------------QEGFTRFRE--RRFHPS 595

  Fly   391 IRPGMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEK-----------RRQLSFEKN-DVV 443
            :|                 ...|..||..:..|||:|..:|           ..:.:...| |:.
Human   596 LR-----------------STRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLP 643

  Fly   444 ELVKLNETAKQPAAEPQVDADGKPIEEKSVPWGPQRKKR----RLHG 486
            :::..:|.:.|||.:.:..|..|...:|.     |..|:    :|:|
Human   644 QVIPKSENSSQPAKKAKGAAKTKQQLQKQ-----QHPKKASFQKLNG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_652007.1	RsmB	13..433	CDD:223222	108/442 (24%)
NOP2	NP_001245238.1	RsmB	290..619	CDD:223222	107/428 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810