DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun2 and Nsun2

DIOPT Version :9

Sequence 1:	NP_652007.1	Gene:	Nsun2 / 45064	FlyBaseID:	FBgn0026079	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_663329.3	Gene:	Nsun2 / 28114	MGIID:	107252	Length:	757	Species:	Mus musculus

Alignment Length:	768	Identity:	323/768 - (42%)
Similarity:	441/768 - (57%)	Gaps:	84/768 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRNQKQNFFAARKRQKRE-----NGPKRTDRQAQ-PYEEIKRDNAFFIKYYQLQKICATDEEWT 59
            |||..:...|....:.:.|     .|.||.....: .|.||.::|..|..|||..|| ..:.||.
Mouse     1 MGRRARGRRFQQPPQPEGEEDASDGGRKRGQAGWEGGYPEIVKENKLFEHYYQELKI-VPEGEWD 64

  Fly    60 QFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNG 124
            ||:.|:|:.||.|.|:||:|..||.:|..::.:.|.|    :.:|.... :.||.|..|.|||..
Mouse    65 QFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKE----LEDLEVDG-QKVEVPQPLSWYPEE 124

  Fly   125 LAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGS 189
            ||:..:|:||.:|:|..|.:.|.||:.||.:|.||||||||||||::|:|.|..|:|||||||||
Mouse   125 LAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGS 189

  Fly   190 KTAQLIEALHA---APEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLV 251
            ||.||||.|||   .|    .|.|||:||||||.|||:||||||||:|||::|.|||:|..|.|
Mouse   190 KTTQLIEMLHADMSVP----FPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRL- 249

  Fly   252 TTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGG 316
            |...||.|.||.:|:||||||||||||:|||.|:|.||....:..|||:|.||..||||.|..||
Mouse   250 TVDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGG 314

  Fly   317 RLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFE 381
            |:|||||||||:|:|||:..:::.::|||||.|....:||||:.||::.||:.|:: .|.|..:.
Mouse   315 RMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRD-GQWFADWH 378

  Fly   382 EVPESLHTIIRPGMFPLPAD--EMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVE 444
            |||:..||.|||.||| |.|  ::..:.||:|||:|||.|::||||||||.|:..:.:.|.. .:
Mouse   379 EVPQGRHTQIRPTMFP-PTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNKRQ-PK 441

  Fly   445 LVKLNETAKQPAAEPQVDA-DGKPIEEK-----------------------------SVPWGPQR 479
            :...:..|::|.....|.| :|.|.::.                             .|...|..
Mouse   442 VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEKKDGVCGPPPS 506

  Fly   480 KKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVL 544
            ||.:|.|:||||:||..|:||.:..|::||.||.|..:..||||....||:.:|..|:.:|:::|
Mouse   507 KKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLL 571

  Fly   545 NNENNIKIINTGVKTFVRCENRHTVH---PFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCT 606
            ||...:|:||||:|  |.|.|.....   .|||||||:.|...|:. ||.|.|..||:..:|.
Mouse   572 NNSEKMKVINTGIK--VWCRNNSGEEFDCAFRLAQEGIYTLYPFIN-SRIITVSMEDVKTLLT-- 631

  Fly   607 DPTQPPSTHELKKETQERCKELGVGSCILKYVDQ-------RFTLYTVGWRGTSSLRAYVQKDET 664
              .:.|...:|..|...:.|:|..||.:|||...       :..:...||||.:|:|.:|.|:|.
Mouse   632 --QENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTLQCPIVLCGWRGKASIRTFVPKNER 694

  Fly   665 IHILRLLGADLSKFETNKYEDARVAAAAAADAEVGKSAEAEADSSGDGDATES 717
            :|.||::|  |......|.|...:....||..|          ..||.||.::
Mouse   695 LHYLRMMG--LEVLGEKKKEGVILTNENAASPE----------QPGDEDAKQT 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_652007.1	RsmB	13..433	CDD:223222	221/430 (51%)
Nsun2	NP_663329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		9/39 (23%)
		RsmB	28..430	CDD:223222	215/407 (53%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	184..190		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..504		22/97 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..757		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836959
Domainoid	1	1.000	308	1.000	Domainoid score	I1335
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9817
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1175
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54313
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002888
OrthoInspector	1	1.000	-	-		oto93457
orthoMCL	1	0.900	-	-		OOG6_101428
Panther	1	1.100	-	-	LDO	PTHR22808
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760