DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and SERPINB11

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001357404.1	Gene:	SERPINB11 / 89778	HGNCID:	14221	Length:	392	Species:	Homo sapiens

Alignment Length:	388	Identity:	115/388 - (29%)
Similarity:	195/388 - (50%)	Gaps:	39/388 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLH-------------ASA 81
            |..::|:.|.::...:|:..|.:|:..||.:...||.|.|..:|:|.||             .|.
Human    11 FCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHFSHTVDSLKPGFKDSP 75

  Fly    82 KESKDGLAESYHNLLHSYIK---SKTVLEIANKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSR 143
            |.|:.|...|...:..|.|.   |...|.|||::|..:.:.....:...::|::.:.::.:||.:
Human    76 KCSQAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGTKTMAFHQQYLSCSEKWYQARLQTVDFEQ 140

  Fly   144 ETEAVEQ-INRWVKQQTENKIERVV--ESLEPDTNVALVNAIYFKARWARPFNDEDTRDREFWLS 205
            .||...: ||.||:.:|..|:..:.  .:::|.:.:.||||||||.:|...|...:|....|.||
Human   141 STEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIYFKGQWQNKFQVRETVKSPFQLS 205

  Fly   206 ESRSIQVPTMFADNWYYYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQKLKGVDF-- 268
            |.:::.|..|:....:..|...|...:.:||.:.|..|:|..:||...:.|:.:|::|....|
Human   206 EGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVNNKLSMIILLPVGIANLKQIEKQLNSGTFHE 270

  Fly   269 -----NLLEDRWQWQSVSVYLPKFKFEFDTDLRPTLHKMGISAMFSDA-ADFSNIFQDSPI-GTR 326
                 |::|     :.|.|:||:||.|...:|...|..:|::.:|:.. ||.|.:   ||. |..
Human   271 WTSSSNMME-----REVEVHLPRFKLETKYELNSLLKSLGVTDLFNQVKADLSGM---SPTKGLY 327

  Fly   327 ITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFIIRDKH--AVYFTGHI 387
            ::|..||:::||:|.|.|||.|:..:....|||:..: |.|:|||.|.||..|  .:.|.|.:
Human   328 LSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLPMRAQ-FKANHPFLFFIRHTHTNTILFCGKL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	115/386 (30%)
SERPINB11	NP_001357404.1	ovalbumin_like	4..392	CDD:239014	115/388 (30%)
SERPINB11	NP_001357404.1	RCL. /evidence=ECO:0000250	341..365		9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830