Protein Alignment Spn43Aa and SERPINB12

DIOPT Version :10

• Sequence 1: NP_524805.1
• Gene: Spn43Aa / 45041
• FlyBaseID: FBgn0024294
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: XP_005266835.2
• Gene: SERPINB12 / 89777
• HGNCID: 14220
• Length: 437
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 120/419 - (28%)
• Similarity: 203/419 - (48%)
• Gaps: 68/419 - (16%)

  Fly    30 FATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLH---ASAKESKD----- 86
            |..:|||.:..|.:.:|:..||:|:..|||:...||...:|.::.:.||   .|..|||:
Human    23 FCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPCL 87

  Fly    87 ----------------------------------GLAESYHNLLHS---YIKSKTVLEIANKVYT 114
                                              ||...|...|.|   .||:...|.|||::|.
Human    88 KSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYG 152

  Fly   115 RQNLTVSSHFREVAQKYFDSEVEPLDFSRETE-AVEQINRWVKQQTENKIERVV--ESLEPDTNV 176
            .|...:...:.:...:::.:.:|.:||.:..| :.::||.||:.|::.||:.:.  :::..:|.:
Human   153 EQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETVL 217

  Fly   177 ALVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTMFADNWYYYADYPELDAKAIELFFENI 241
            .||||:||||:|...|:.|:|.|..|.|:.:.:..|..|.....|......|:.|:.:|:.:...
Human   218 VLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKG 282

  Fly   242 NLTMWFILPNQR----SGLQALEQKL---KGVDFNLLEDRWQWQSVSVYLPKFKFEFDTDLRPTL 299
            .|:|:.:||:..    .||:.||:|:   |.|.::..|:..: :||.:..|:|..|...||...|
Human   283 KLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSE-ESVVLSFPRFTLEDSYDLNSIL 346

  Fly   300 HKMGISAMFSDA-ADFSNIFQDSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPK 363
            ..|||:.:|.:. ||.:.| ..|| ...::|:.||||::|:|.|.:||.|:.|.....||    :
Human   347 QDMGITDIFDETRADLTGI-SPSP-NLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSL----R 405

  Fly   364 TFV---ADHPFAFIIRDK--HAVYFTGHI 387
            ::|   |:|||.|.||..  ..:.|.|.:
Human   406 SWVEFNANHPFLFFIRHNKTQTILFYGRV 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	serpin42Dd-like_insects	27..390	CDD:381070	120/419 (29%)
SERPINB12	XP_005266835.2	serpinB12_yukopin	13..437	CDD:381037	120/419 (29%)