DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Aa and SERPINA6

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	376	Identity:	115/376 - (30%)
Similarity:	189/376 - (50%)	Gaps:	31/376 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GLGNTIKDRNLFATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLHASAKE 83
            ||.:...|   ||..|::.|......:|:.||||||.:||.:...|..|.|.|:|.:.|..:..|
Human    38 GLASANVD---FAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTE 99

  Fly    84 -SKDGLAESYHNLLHSYIKSKTVLE--IANKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSRET 145
             |:..:.:.:.:|...:.||.|.||  :.|.::...:|.:...|....:.|::|||..::|....
Human   100 RSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWA 164

  Fly   146 EAVEQINRWVKQQTENKIERVVESLEPDTNVALVNAIYFKARWARPFNDEDTRDREFWLSESRSI 210
            .|..|||.:||.:|:.||..:...|:....:.|||.|:||..|.:||:...||:..|::.|:..:
Human   165 TASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVV 229

  Fly   211 QVPTMFADNWYYYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQKLKGVDFNLLED-- 273
            :||.|...:...|....||..:.:::.:.. |.|::||||:        :.|:..|...|..|
Human   230 KVPMMLQSSTISYLHDSELPCQLVQMNYVG-NGTVFFILPD--------KGKMNTVIAALSRDTI 285

  Fly   274 -RWQ----WQSVSVYLPKFKFEFDTDLRPTLHKMGISAMFSDAADFSNIFQDSPIGTRITKVQHK 333
             ||.    ...|.:|:||.......||...|.:|||:.:|::.|:||.|.||:.:  :.:||.||
Human   286 NRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQL--KSSKVVHK 348

  Fly   334 TFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFIIRDKHAVYFT 384
            ..:.:||.|.:.||::   ||.::|...|.....:.||..:|.|    :||
Human   349 AVLQLNEEGVDTAGST---GVTLNLTSKPIILRFNQPFIIMIFD----HFT 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	112/367 (31%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	113/372 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.970