DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Spn43Aa and SERPING1

DIOPT Version :9

Sequence 1:NP_524805.1 Gene:Spn43Aa / 45041 FlyBaseID:FBgn0024294 Length:390 Species:Drosophila melanogaster
Sequence 2:NP_000053.2 Gene:SERPING1 / 710 HGNCID:1228 Length:500 Species:Homo sapiens


Alignment Length:389 Identity:102/389 - (26%)
Similarity:177/389 - (45%) Gaps:56/389 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LGNTIKDRNLFATELFQTL-ATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLHASAKE 83
            ||:.:.|   |:.:|:... |..:.:.|:..||.||...|.....||...|...|:..|      
Human   142 LGDALVD---FSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESIL------ 197

  Fly    84 SKDGLAESY---HNLLHSYIKSKTVLEI--ANKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSR 143
                   ||   ...:|..:|..|...:  .::::...:|.:...|...::..:.|  .|...|.
Human   198 -------SYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSS--SPRVLSN 253

  Fly   144 ETEA-VEQINRWVKQQTENKIERVVESLEPDTNVALVNAIYFKARWARPFNDEDTRDREFWLSES 207
            .::| :|.||.||.:.|.|||.|:::||..||.:.|:||||..|:|...|:.:.||...|....|
Human   254 NSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNS 318

  Fly   208 RSIQVPTMFADNW--YYYADYPELDAKAIELFFENINLTMWFILP-NQRSGLQALEQKLKGVDFN 269
             .|:||.|.:..:  .::.| ..|.||..:|...: ||::..::| |.:..|:.:||.|....|.
Human   319 -VIKVPMMNSKKYPVAHFID-QTLKAKVGQLQLSH-NLSLVILVPQNLKHRLEDMEQALSPSVFK 380

  Fly   270 LLEDRWQ---WQSVSVYLPKFKFEFDTDLRPTLHKMGISAMFSDAADFS------NIFQDSPIGT 325
            .:.::.:   :|...:.||:.|.....|:...:.|:       :..|||      .:.:|..:  
Human   381 AIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKL-------EFFDFSYDLNLCGLTEDPDL-- 436

  Fly   326 RITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFIIRDKHAVY--FTGHI 387
            :::.:||:|.:::.|.|.|||.|| |..|..:|    ..|....||.|::.|:...:  |.|.:
Human   437 QVSAMQHQTVLELTETGVEAAAAS-AISVARTL----LVFEVQQPFLFVLWDQQHKFPVFMGRV 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spn43AaNP_524805.1 SERPIN 28..387 CDD:238101 99/379 (26%)
SERPING1NP_000053.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..118
7 X 4 AA tandem repeats of [QE]-P-T-[TQ] 85..119
C1_inh 145..495 CDD:239005 100/384 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11461
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.