DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serpina3i

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_017170641.1	Gene:	Serpina3i / 628900	MGIID:	2182841	Length:	457	Species:	Mus musculus

Alignment Length:	401	Identity:	121/401 - (30%)
Similarity:	187/401 - (46%)	Gaps:	55/401 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TIKDRNL-FATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLHASAKESKD 86
            |:...|. ||..|::.|.....||||:.||.||..||.|...||:..|..|:.:.|..:..|:.:
Mouse    71 TVASSNTDFAFSLYRKLVLKNPDENVVFSPFSIFTALALLSLGAKSNTLKEILEGLKFNLTETPE 135

  Fly    87 -GLAESYHNLLH--SYIKSKTVLEIANKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSRETEAV 148
             .:.:.:..||.  |....:..:...:.::..::|.:.:.|:|.|:..:.:|....||.:..:|.
Mouse   136 PDIHQGFRYLLDLLSQPGDQVQISTGSALFVEKHLQILAEFKEKARALYQAEAFTADFLQPCQAK 200

  Fly   149 EQINRWVKQQTENKIERVVESLEPDTNVALVNAIYFK--------------ARWARPFNDEDTRD 199
            :.||.:|..||:.||:.::..|:..|.:.|||.||||              .:|..||:..||.:
Mouse   201 KLINDYVSNQTQGKIKELISDLDKSTLMVLVNYIYFKGGRGHCLGVEREELGKWKMPFDPRDTFN 265

  Fly   200 REFWLSESRSIQVPTMFADNWY--YYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQK 262
            .:|:|.|.||::||.|..:...  |:.| .||....:||.:.. |.:..||||:| ..:|.:|..
Mouse   266 SKFYLDEKRSVKVPMMKIEELTTPYFRD-DELSCSVVELKYTG-NASALFILPDQ-GKMQQVETS 327

  Fly   263 LKGVDFNLLEDRWQWQS-------VSVYLPKFKFEFDTDLRPTLHKMGISAMFSDAADFSNIFQD 320
            |..      |...:|::       ..::||||....|..|...|..:||..:||..||.|.|
Mouse   328 LHP------ETLRKWKNSLKPSRISELHLPKFSISNDYSLEHVLPVLGIREVFSMQADLSAI--- 383

  Fly   321 SPIGT---RITKVQHKTFIDVNEIGCEAAGASYAAGVPMSL---PLDPKTFVADHPFAFIIRDKH 379
              .||   |:::|.||..:||.|.|.|||.|:   ||.::|   .:...|.....||..||.|
Mouse   384 --TGTMDLRVSQVVHKAVLDVTETGTEAAAAT---GVKVNLRCGKIYSMTIYFKRPFLIIISD-- 441

  Fly   380 AVYFTGHIVKF 390
               ...||..|
Mouse   442 ---INTHIALF 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	117/391 (30%)
Serpina3i	XP_017170641.1	serpinA3_A1AC	62..457	CDD:381019	121/401 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010