DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and SERPINB10

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_005015.1	Gene:	SERPINB10 / 5273	HGNCID:	8942	Length:	397	Species:	Homo sapiens

Alignment Length:	401	Identity:	119/401 - (29%)
Similarity:	203/401 - (50%)	Gaps:	56/401 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NLFATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLH-----------ASA 81
            |.||.||.:.||...|.:|:..|..||..:|.:.|.||:|.|||::.:.|.           .|.
Human     9 NQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCDPESE 73

  Fly    82 KESK--------DGLAESYHNLLHSYIKSKT--VLEIANKVYTRQNLTVSSHFREVAQKYFDSEV 136
            |:.|        :.:...:..|:...:|...  :|:.||.:|..:.....:.:.|..:.||.:|.
Human    74 KKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEP 138

  Fly   137 EPLDFSRETEAV-EQINRWVKQQTENKIERVV--ESLEPDTNVALVNAIYFKARWARPFNDEDTR 198
            :|::|...::.: :.||.||::|||.||:.::  :|::..|.:.||||:|||..|...|..::|.
Human   139 QPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTT 203

  Fly   199 DREFWLSESRSIQVPTMFADNWYYYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQKL 263
            ::.|.::|:.|..|..||.....:.....:..|..::|::::.:|::..:||...:||:.||
Human   204 EKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLE--- 265

  Fly   264 KGVDFNLLEDRWQWQS--------VSVYLPKFKFEFDTDLRPTLHKMGISAMFSDA-ADFS---- 315
            |.:.:..|.   :|.|        |.::|||||.|...||:.||..||:|..||.: ||||
Human   266 KAITYEKLN---EWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSS 327

  Fly   316 --NIFQDSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFIIRDK 378
              |:|        ::.|.||.|:::||.|.|||..| .:.:.:.:.:....|.|:|||.|.||..
Human   328 ARNLF--------LSNVFHKAFVEINEQGTEAAAGS-GSEIDIRIRVPSIEFNANHPFLFFIRHN 383

  Fly   379 --HAVYFTGHI 387
              :.:.|.|.:
Human   384 KTNTILFYGRL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	119/399 (30%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	119/401 (30%)
SERPINB10	NP_005015.1	Nuclear localization signal	74..77		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830