DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and SERPINA4

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001275961.1	Gene:	SERPINA4 / 5267	HGNCID:	8948	Length:	464	Species:	Homo sapiens

Alignment Length:	371	Identity:	101/371 - (27%)
Similarity:	180/371 - (48%)	Gaps:	18/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLHASAKE-SKDGLAESYH 93
            ||...:..:|::...:|:..||:||..|..:...||...:.:::.:.|..:..| |:..:...:.
Human    95 FAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNLTELSESDVHRGFQ 159

  Fly    94 NLLHSYIKSKTVLE--IANKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSRETEAVEQINRWVK 156
            :|||:.......||  :.:.::...||...:.|.......:::::...:|......::.||..||
Human   160 HLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFHTNFYDTVGTIQLINDHVK 224

  Fly   157 QQTENKIERVVESLEPDTNVALVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTMFAD--- 218
            ::|..||..:|..|:.|..:.|||.|||||.|.:||....|..::|::.|:.:::||.|..|
Human   225 KETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEH 289

  Fly   219 NWYYYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQKLKGVDF----NLLEDRWQWQS 279
            :||.:..|  |....:.:.::. :.|::|||||| ..::.:|:.|.....    |||..|..::.
Human   290 HWYLHDRY--LPCSVLRMDYKG-DATVFFILPNQ-GKMREIEEVLTPEMLMRWNNLLRKRNFYKK 350

  Fly   280 VSVYLPKFKFEFDTDLRPTLHKMGISAMFSDAADFSNIFQDSPIGTRITKVQHKTFIDVNEIGCE 344
            :.::||||.......|...|.::|.:.:||..||.|.|.:...:  ..:|..||..:||:|.|.|
Human   351 LELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKL--EASKSFHKATLDVDEAGTE 413

  Fly   345 AAGASYAAGVPMSLPLDPKTFVADHPFAFII--RDKHAVYFTGHIV 388
            ||.|:..|....|...:......:.||..:|  ....:|.|.|.:|
Human   414 AAAATSFAIKFFSAQTNRHILRFNRPFLVVIFSTSTQSVLFLGKVV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	100/368 (27%)
SERPINA4	NP_001275961.1	alpha-1-antitrypsin_like	91..458	CDD:239011	100/368 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020