DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serpina3m

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001257911.1	Gene:	Serpina3m / 299276	RGDID:	735068	Length:	419	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	118/414 - (28%)
Similarity:	201/414 - (48%)	Gaps:	36/414 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSIILLGVW---ISAPEG-LGN-----------------TIKDRNL-FATELFQTLATDRQDENV 47
            |.:::.|:.   :..|:| |||                 |::..|. ||..|::.||....|:||
  Rat     7 LGLLMAGICPAVLGFPDGTLGNDTLLHKDQDKGTQLDSLTLESINTDFAFSLYKMLALKNPDKNV 71

  Fly    48 IISPVSIQLALGLAYYGAEGRTAAELQKTLHASAKES-KDGLAESYHNLLHSYIKSKTVLEI--A 109
            :.||:||..||.:...||:|.|..|:.:.|..:..|| :..:.:.:.:||....:....::|  .
  Rat    72 VFSPLSISAALAIVSLGAKGNTLEEILEVLRFNLTESYETDIHQGFGHLLQRLSQPGDQVKIITG 136

  Fly   110 NKVYTRQNLTVSSHFREVAQKYFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESLEPDT 174
            |.::..:||.|.:.|:|..:..:..|....||.:.....:.||.:|:.||:.||:.:|..|:..|
  Rat   137 NALFIDKNLQVLAEFQEKTRALYQVEAFTADFQQPRVTEKLINDYVRNQTQGKIQELVSGLKERT 201

  Fly   175 NVALVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTMFADNWY--YYADYPELDAKAIELF 237
            ::.|||.:.|:.:|..||:.:.|.:.||::.|.||::|..|..:...  |:.| .||....:||.
  Rat   202 SMVLVNYLLFRGKWKVPFDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFRD-EELSCSVLELK 265

  Fly   238 FENINLTMWFILPNQRSGLQALEQKLKGVDFNLLEDRWQWQSV-SVYLPKFKFEFDTDLRPTLHK 301
            :.. |.:..||||: :..:|.:|..|:.......:|..:.:.: .:|||:.....|..|...|.:
  Rat   266 YTG-NSSALFILPD-KGRMQQVEASLQPETLKKWKDSLRPRKIDELYLPRLSISTDYSLEEVLPE 328

  Fly   302 MGISAMFSDAADFSNIFQDSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFV 366
            :||..:||..||.|.|.....:.  :::|.||..:||||.|.|||.|:.|..||.| ...|....
  Rat   329 LGIRDVFSQQADLSRITGAKDLS--VSQVVHKVVLDVNETGTEAAAATGANLVPRS-GRPPMIVW 390

  Fly   367 ADHPFAFIIRDKH--AVYFTGHIV 388
            .:.||...:...|  .:.|...::
  Rat   391 FNRPFLIAVSHTHGQTILFMAKVI 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	110/367 (30%)
Serpina3m	NP_001257911.1	SERPIN	56..416	CDD:214513	107/365 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010