DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Aa and Serpina6

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001009663.1	Gene:	Serpina6 / 299270	RGDID:	1595901	Length:	396	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	111/393 - (28%)
Similarity:	194/393 - (49%)	Gaps:	40/393 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLSIILLGVWI---------SAPEGLGNTIKDRNLFATELFQTLATDRQDENVIISPVSIQLALG 59
            ||  ...|:|.         ::..||..|..|   ||..|:|.|.....|:|.:||||||.:||.
  Rat    11 WL--CTSGLWTAQASTNESSNSHRGLAPTNVD---FAFNLYQRLVALNPDKNTLISPVSISMALA 70

  Fly    60 LAYYGAEGRTAAELQKTLHASAKESKDGLAESYHNLLHSYIKSKTVLE--IANKVYTRQNLTVSS 122
            :...|:  .....||.......:.|:..:.:|:..|.:...:|.|.||  :.|.::..|.|.:..
  Rat    71 MVSLGS--AQTQSLQSLGFNLTETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKD 133

  Fly   123 HFREVAQKYFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESLEPDTNVALVNAIYFKAR 187
            .|....::|::||...:||...|:|.:|||:.||.:|:.|||.|...|:...:..|||.|:.:..
  Rat   134 SFLADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGI 198

  Fly   188 WARPFNDEDTRDREFWLSESRSIQVPTMF-ADNWYYYAD--YPELDAKAIELFFENINLTMWFIL 249
            |..||:.|:||:.:|:::|:.:::||.|. :.:..|:.|  :|   .:.|::.:.. |.|.:|||
  Rat   199 WELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFP---CQLIQMDYVG-NGTAFFIL 259

  Fly   250 PNQRSGLQALEQKLKGVDFNLLEDRW----QWQSVSVYLPKFKFEFDTDLRPTLHKMGISAMFSD 310
            |:|..    ::..:..:..:.: |||    ..:.|::|:|||......||:..|..:.|..:.::
  Rat   260 PDQGQ----MDTVIAALSRDTI-DRWGKLMTPRQVNLYIPKFSISDTYDLKDMLEDLNIKDLLTN 319

  Fly   311 AADFSNIFQDSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFII 375
            .:|||...:|.|:  .:|.| ||..:.::|........:   |.|:.|..:|.....:.||..::
  Rat   320 QSDFSGNTKDVPL--TLTMV-HKAMLQLDEGNVLPNSTN---GAPLHLRSEPLDIKFNKPFILLL 378

  Fly   376 RDK 378
            .||
  Rat   379 FDK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	103/360 (29%)
Serpina6	NP_001009663.1	alpha-1-antitrypsin_like	37..392	CDD:239011	105/365 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110