DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serpina1d

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_033272.1	Gene:	Serpina1d / 20703	MGIID:	891968	Length:	413	Species:	Mus musculus

Alignment Length:	422	Identity:	114/422 - (27%)
Similarity:	205/422 - (48%)	Gaps:	57/422 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLSIILLGVWISAPEGLGNTI-------KDR---------NL--FATELFQTLATDRQDENVIIS 50
            |..::|.|:....|..|...:       ||:         ||  ||..|::.|.......|:..|
Mouse     7 WSLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFALRLYRELVHQSNTSNIFFS 71

  Fly    51 PVSIQLALGLAYYGAEGRTAAELQKTLHASAKESKDG-LAESYHNLLHSYIKSKTVLEIA--NKV 112
            ||||..|..:...|::|.|..::.:.|..:..::.:. :.:|:.:||.:..:..:.|:::  |.:
Mouse    72 PVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGL 136

  Fly   113 YTRQNLTVSSHFREVAQKYFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESLEPDTNVA 177
            :...:|.:...|.|.|:.::.:||..::|:...||.:.||.:|::.|:.||...|:.|:.||..|
Mouse   137 FVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLDQDTVFA 201

  Fly   178 LVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTM------------FADNWYYYADYPELD 230
            |.|.|.||.:|.:||:.|:|.:.||.:.||.:::||.|            ...:|....||..
Mouse   202 LANYILFKGKWKQPFDPENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSMLSSWVLLMDYAG-- 264

  Fly   231 AKAIELFFENINLTMWFILPNQRSGLQALEQKL-KGVDFNLLEDRWQWQSVSVYLPKFKFEFDTD 294
                       |.|..|:||:. ..:|.|||.| |.:....|.:| :.....:::|:.....:.:
Mouse   265 -----------NTTAVFLLPDD-GKMQHLEQTLNKELISQFLLNR-RRSDAQIHIPRLSISGNYN 316

  Fly   295 LRPTLHKMGISAMFSDAADFSNIFQD-SPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSL 358
            |:..:..:||:.:|::.||.|.|.:: :|:  :::|..||..:.::|.|.|||.|:.......|:
Mouse   317 LKTLMSPLGITRIFNNGADLSGITEENAPL--KLSKAVHKAVLTIDETGTEAAAATVLQVATYSM 379

  Fly   359 PLDPKTFVADHPFAFIIRDKH--AVYFTGHIV 388
               |.....||||.|||.::|  :..|.|.:|
Mouse   380 ---PPIVRFDHPFLFIIFEEHTQSPIFVGKVV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	106/379 (28%)
Serpina1d	NP_033272.1	SERPIN	53..410	CDD:214513	103/376 (27%)
Serpina1d	NP_033272.1	RCL	368..387		3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010