DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serpina1c

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_033271.1	Gene:	Serpina1c / 20702	MGIID:	891969	Length:	413	Species:	Mus musculus

Alignment Length:	424	Identity:	115/424 - (27%)
Similarity:	204/424 - (48%)	Gaps:	61/424 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLSIILLGVWISAPEGLGNTI-------KDR---------NL--FATELFQTLATDRQDENVIIS 50
            |..::|.|:....|..|...:       ||:         ||  ||..|::.|.......|:..|
Mouse     7 WGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFS 71

  Fly    51 PVSIQLALGLAYYGAEGRTAAELQKTLHASAKESKDG-LAESYHNLLHSYIKSKTVLEIA--NKV 112
            ||||..|..:...|::|.|..::.:.|..:..::.:. :.:|:.:||.:..:..:.|:::  |.:
Mouse    72 PVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGL 136

  Fly   113 YTRQNLTVSSHFREVAQKYFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESLEPDTNVA 177
            :...:|.:...|.|.|:.::.:||..::|:...||.:.||.:|::.|:.||...|:.|:.||..|
Mouse   137 FVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFA 201

  Fly   178 LVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTM------------FADNWYYYADYPELD 230
            |.|.|.||.:|.:||:.|:|.:.||.:.||.:::||.|            ...:|....||..
Mouse   202 LANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAG-- 264

  Fly   231 AKAIELFFENINLTMWFILPNQRSGLQALEQKLKG---VDFNLLEDRWQWQSVSVYLPKFKFEFD 292
                       |.|..|:||:. ..:|.|||.|..   ..|.|...|   :...::.|:.....:
Mouse   265 -----------NATAVFLLPDD-GKMQHLEQTLSKELISKFLLKRPR---RLAQIHFPRLSISGE 314

  Fly   293 TDLRPTLHKMGISAMFSDAADFSNIFQD-SPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPM 356
            .:|:..:..:||:.:|::.||.|.|.:: :|:  ::::..||..:.::|.|.|||.|:....||.
Mouse   315 YNLKTLMSPLGITRIFNNGADLSGITEENAPL--KLSQAVHKAVLTMDETGTEAAAATVLLAVPY 377

  Fly   357 SLPLDPKTFVADHPFAFIIRDKH--AVYFTGHIV 388
            |:   |.....||||.|||.::|  :..|.|.:|
Mouse   378 SM---PPIVRFDHPFLFIIFEEHTQSPLFVGKVV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	107/381 (28%)
Serpina1c	NP_033271.1	SERPIN	53..410	CDD:214513	104/378 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010