DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serping1

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	395	Identity:	96/395 - (24%)
Similarity:	174/395 - (44%)	Gaps:	59/395 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SAPEGLGNTIKDRNLFATELFQTL-ATDRQDENVIISPVSIQLALGLAYYGAEGRTAAELQKTLH 78
            |:...|...:.|   |:.:|:... ||.....|:..||.||...|.....||...|.:.|:..|
Mouse   142 SSEAKLSEALTD---FSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESIL- 202

  Fly    79 ASAKESKDGLAESY-------HNLLHSYIKSKTVLEIANKVYTRQNLTVSSHFREVAQKYFDSEV 136
                        ||       |..|..: .||.|..: ::::...:|.:...:...:|..:.|
Mouse   203 ------------SYPKDFACVHQALKGF-SSKGVTSV-SQIFHSPDLAIRDTYVNASQSLYGS-- 251

  Fly   137 EPLDFSRETEA-VEQINRWVKQQTENKIERVVESLEPDTNVALVNAIYFKARWARPFNDEDTRDR 200
            .|.....::.| :|.||.||.:.|.:||.::::||..||.:.|:||:|..|:|...|..:.....
Mouse   252 SPRVLGPDSAANLELINTWVAENTNHKIRKLLDSLPSDTCLVLLNAVYLSAKWKITFEPKKMMAP 316

  Fly   201 EFWLSESRSIQVPTMFADNWYYYADYPE--LDAKAIELFFENINLTMWFILP-NQRSGLQALEQK 262
            .|:  ::..|:|| |.:...|..|.:.:  |.||..:|...: ||:...::| ..:..|:.:|:.
Mouse   317 FFY--KNSMIKVP-MMSSVKYPVAQFDDHTLKAKVGQLQLSH-NLSFVIVVPVFPKHQLKDVEKA 377

  Fly   263 LKGVDFNLLEDRWQWQSVSVYLPKF------KFEFDTDLRPTLHKMGISAMFSDAADFS--NIFQ 319
            |....|..:..:.:   :|.:||.:      |.:...|:...:.|:   ..|....|.:  .:.:
Mouse   378 LNPTVFKAIMKKLE---LSKFLPTYLTMPHIKVKSSQDMLSVMEKL---EFFDFTYDLNLCGLTE 436

  Fly   320 DSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFAFIIRDKHAVY-- 382
            |..:  :::.::|:|.:::.|.|.|||.|| |.....|||:    |....||.|::.|:...:
Mouse   437 DPDL--QVSAMKHETVLELTESGVEAAAAS-AISFGRSLPI----FEVQRPFLFLLWDQQHRFPV 494

  Fly   383 FTGHI 387
            |.|.:
Mouse   495 FMGRV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	93/380 (24%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	96/395 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010