DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Aa and Serpini1

DIOPT Version :9

Sequence 1:	NP_524805.1	Gene:	Spn43Aa / 45041	FlyBaseID:	FBgn0024294	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_446231.1	Gene:	Serpini1 / 116459	RGDID:	619896	Length:	410	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	122/408 - (29%)
Similarity:	210/408 - (51%)	Gaps:	43/408 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSIILLGVWISAPEGLGNTIKDRNLFATELFQTLATDRQDENVIISPVSIQLALGLAYYGAEGRT 69
            ||::.|...::.......||.:   ::..::..|....:|||::.||:||.||:|:...||:|.|
  Rat     7 LSLVALQSLVTGAAFPDETIAE---WSVNVYNHLRATGEDENILFSPLSIALAMGVMELGAQGST 68

  Fly    70 AAELQKTLHASAKES-KDGLAESYHNLLHSYIKSKT---VLEIANKVYTRQNLTVSSHFREVAQK 130
            ..|::   |:...|| |.|...|:.....|.:.::.   |::|||.::.:....::..|.::.:.
  Rat    69 LKEIR---HSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMMKM 130

  Fly   131 YFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESLEPD--TNVALVNAIYFKARWARPFN 193
            ||::||..:|||........||:||:..|.:.::.:|...:.|  |::||:||:|||..|...|.
  Rat   131 YFNAEVNHVDFSENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKSQFR 195

  Fly   194 DEDTRDREFWLSESRSIQVPTMFADNWYYYADYPELDAKA------IELFFENINLTMWFILPNQ 252
            .|:||...|...:...:|:|.|:....:||.::.:...:|      :|:.:|...::|..:|..|
  Rat   196 PENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQ 260

  Fly   253 RSGLQALEQKLKGVDFNLLEDRW----QWQSVSVYLPKFKFEFDTDLRPTLHKMGISAMF-SDA- 311
            ...|..||..||.   .|:|: |    :.|.|.||||:|..|.:.||:..|..:|::.:| .||
  Rat   261 EVPLATLEPLLKP---QLIEE-WANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDAN 321

  Fly   312 ----ADFSNIFQDSPIGTRITKVQHKTFIDVNEIGCEAAGASYAAGVPMSLPLDPKTFVADHPFA 372
                :|...:|        ::|..||:||:|||.|.|||.||....:.....|.|:..| ||||.
  Rat   322 LTAMSDKKELF--------LSKAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIV-DHPFL 377

  Fly   373 FIIRDKH--AVYFTGHIV 388
            |:|:::.  .:.|.|.::
  Rat   378 FLIKNRKTGTILFMGRVM 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Aa	NP_524805.1	SERPIN	28..387	CDD:238101	117/382 (31%)
Serpini1	NP_446231.1	neuroserpin	23..410	CDD:239003	119/392 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830