DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINB11

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001357404.1	Gene:	SERPINB11 / 89778	HGNCID:	14221	Length:	392	Species:	Homo sapiens

Alignment Length:	391	Identity:	101/391 - (25%)
Similarity:	193/391 - (49%)	Gaps:	49/391 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLR-------LGPGDADAV--- 89
            |::..:.::::.:|:..|..::..::::..:||:|:|..:|::.|.       |.||..|:.
Human    14 DVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHFSHTVDSLKPGFKDSPKCS 78

  Fly    90 ------SQRSGSYQQALTRDNN--FRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYN 146
                  |:....:.|....|:|  ..:||.:|..:.:.|...:...:::.:.:.:..:||... .
Human    79 QAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGTKTMAFHQQYLSCSEKWYQARLQTVDFEQS-T 142

  Fly   147 KRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSG 211
            :.|...||..|..|||||:.::.....::..:..|:||.:.:...||..|::.:|.|..|:...|
Human   143 EETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIYFKGQWQNKFQVRETVKSPFQLSEG 207

  Fly   212 QSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSL--------- 267
            ::|.|:.|:.:..|..|.|.....:|:||||.|...||::|||.....|:.:::.|
Human   208 KNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVNNKLSMIILLPVGIANLKQIEKQLNSGTFHEWT 272

  Fly   268 SGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSR-DGDFGNM---YRMFVSH 328
            |..|       |.:::|||.||:|.:.....|....|.|||..:|:: ..|...|   ..:::|.
Human   273 SSSN-------MMEREVEVHLPRFKLETKYELNSLLKSLGVTDLFNQVKADLSGMSPTKGLYLSK 330

  Fly   329 FINAVEHKANVEVTEAGVDQPLETG---LLKGLFSRSKKFEADHPFVFAIK--YKDSIAFIGHIA 388
            .|    ||:.::|:|.|.:....||   .:|.|..|: :|:|:|||:|.|:  :.::|.|.|.:|
Human   331 AI----HKSYLDVSEEGTEAAAATGDSIAVKSLPMRA-QFKANHPFLFFIRHTHTNTILFCGKLA 390

  Fly   389 N 389
            :
Human   391 S 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	100/387 (26%)
SERPINB11	NP_001357404.1	ovalbumin_like	4..392	CDD:239014	101/391 (26%)
SERPINB11	NP_001357404.1	RCL. /evidence=ECO:0000250	341..365		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930