Protein Alignment Spn43Ab and SERPINB12

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_005266835.2
• Gene: SERPINB12 / 89777
• HGNCID: 14220
• Length: 437
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 93/423 - (21%)
• Similarity: 180/423 - (42%)
• Gaps: 80/423 - (18%)

  Fly    35 DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGP---------------- 83
            ||:..:..|..::|:..||.::.:::.:..:||:..:|.::.:.|....
Human    26 DLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPCLKSN 90

  Fly    84 -----GDA---------DAVSQRSGS-----------YQQALTR------DNNFRLANNIYINEN 117
                 .|:         :.:.|::||           :.|.|::      |....:||.:|..:.
Human    91 KQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQE 155

  Fly   118 LEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVI 182
            ......:.|...:.:.:.|:.:||.....|...: ||..|..::.|||.::...:.:|..|..|:
Human   156 FPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQE-INFWVECQSQGKIKELFSKDAINAETVLVL 219

  Fly   183 VNGVSYSAAWQKAFRLDKTEKRSF--RTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNP 245
            ||.|.:.|.|:..|..:.|....|  .....:|||:.|...|....:.|  .:.|:::|:.|...
Human   220 VNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIE--EVKAQILEMRYTKG 282

  Fly   246 DFSMLLLLPNR-KD---GLRSLQQSLSGKNLLAEIGA--MSQQKVEVLLPKFSVTFGLGLEGPFK 304
            ..||.:|||:. ||   ||..|::.::.:.::|...:  ||::.|.:..|:|::.....|....:
Human   283 KLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQ 347

  Fly   305 KLGVHTMFSRD-------GDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRS 362
            .:|:..:|...       ....|:|       ::.:.||..|||.|.|......||.:  :..||
Human   348 DMGITDIFDETRADLTGISPSPNLY-------LSKIIHKTFVEVDENGTQAAAATGAV--VSERS 403

  Fly   363 KK----FEADHPFVFAIKYK--DSIAFIGHIAN 389
            .:    |.|:|||:|.|::.  .:|.|.|.:.:
Human   404 LRSWVEFNANHPFLFFIRHNKTQTILFYGRVCS 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	93/423 (22%)
SERPINB12	XP_005266835.2	serpinB12_yukopin	13..437	CDD:381037	93/423 (22%)