DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINB7

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001035237.1	Gene:	SERPINB7 / 8710	HGNCID:	13902	Length:	380	Species:	Homo sapiens

Alignment Length:	373	Identity:	92/373 - (24%)
Similarity:	182/373 - (48%)	Gaps:	27/373 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRL--GPGDADAVSQRSGSYQ 97
            :|:..:..:..|.||..|..::.:::||..:||:..:.|::.:.|.:  ..|..::.:.:||...
Human    14 NLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQS 78

  Fly    98 Q---------ALTRDNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGI 153
            |         |..:|.:..:.|.::..:...|...:.:.|::.:|:.::::|| ..:.:.|...|
Human    79 QLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDF-TNHLEDTRRNI 142

  Fly   154 NRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDT 218
            |:.|..:|:|||.:::....::.....|:||.|.:...||.||...:|....|::.......|..
Human   143 NKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAM 207

  Fly   219 MWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLL--AEIGAMSQ 281
            |...:.||.:.:.....|::||.| |...:|.:|||  ::.|..::..|:.:||:  .....|:.
Human   208 MHQERKFNLSVIEDPSMKILELRY-NGGINMYVLLP--ENDLSEIENKLTFQNLMEWTNPRRMTS 269

  Fly   282 QKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRD-GDFGNMY---RMFVSHFINAVEHKANVEVT 342
            :.|||..|:|.:.....::...:.||:..:|... .|...:.   |:::|..:    ||:.:|||
Human   270 KYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMM----HKSYIEVT 330

  Fly   343 EAGVDQPLETG--LLKGLFSRSKKFEADHPFVFAIKYKDSIAFIGHIA 388
            |.|.:....||  :::....:|..|.|||||:|.|:..|.|.|.|.::
Human   331 EEGTEATAATGSNIVEKQLPQSTLFRADHPFLFVIRKDDIILFSGKVS 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	92/370 (25%)
SERPINB7	NP_001035237.1	serpinB7_megsin	1..380	CDD:381032	92/373 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930