Protein Alignment Spn43Ab and SERPINH1

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_001226.2
• Gene: SERPINH1 / 871
• HGNCID: 1546
• Length: 418
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 97/373 - (26%)
• Similarity: 178/373 - (47%)
• Gaps: 22/373 - (5%)

  Fly    27 ADRNL-LAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVS 90
            |:|:. ||..||.|:|.|...||:::||..:.||:.|..:|.|..|||:.:..|.......:.|.
Human    44 AERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVH 108

  Fly    91 QRSGSYQQALT----RDNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTA- 150
            ...|...::|:    |:..::|.:.:|...::.|...|...:::.::....|::|.   :||:|
Human   109 AGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFR---DKRSAL 170

  Fly   151 DGINRAVATKTNGKITDILRAELLNDRTEG-VIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSV 214
            ..||...|..|:||:.::.:..   :||:| ::||.:.:...|.:.|.....:.|.|......:|
Human   171 QSINEWAAQTTDGKLPEVTKDV---ERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTV 232

  Fly   215 KVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLLAEIGAM 279
            .|..|.....:||.:......::||:|..:...|:::|:|:..:.|..|::.|:.:.|...:|.|
Human   233 GVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKM 297

  Fly   280 SQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSH--FINAVEHKANVEVT 342
            .::.|.:.|||..|.....|:.....||:....  |.:..::.||....  ::.:|.|....|:.
Human   298 QKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAI--DKNKADLSRMSGKKDLYLASVFHATAFELD 360

  Fly   343 EAGVDQPLETGLLKGLFSRSKK-FEADHPFVFAIK--YKDSIAFIGHI 387
            ..|  .|.:..:......||.| |.|||||:|.::  ...|:.|||.:
Human   361 TDG--NPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRL 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	97/373 (26%)
SERPINH1	NP_001226.2	serpinH1_CBP1	36..417	CDD:381003	97/373 (26%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	415..418