Protein Alignment Spn43Ab and SERPINA6

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_047287783.1
• Gene: SERPINA6 / 866
• HGNCID: 1540
• Length: 462
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 97/471 - (20%)
• Similarity: 190/471 - (40%)
• Gaps: 98/471 - (20%)

  Fly     3 VIISCLLLL----LATV-SQSKTVGYDAAAD--RNLLAAD------LYNAVAADHLNENVVISPA 54
            ::.:|||.|    |.|| :......|...::  |.|.:|:      ||..:.|....:|:.|||.
Human     4 LLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPV 68

  Fly    55 TIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGS---------YQQALTRDNNFR--L 108
            :|..::|:..:|..|.|.::|.|||...      :::||.:         :|.....|.:..  :
Human    69 SISMALAMLSLGTCGHTRAQLLQGLGFN------LTERSETEIHQGFQHLHQLFAKSDTSLEMTM 127

  Fly   109 ANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTAD-GINRAVATKTNGKITDI---- 168
            .|.::::.:||...||....:..::|.:..::|.   :..||. .||..|..||.|||.|:
Human   128 GNALFLDGSLELLESFSADIKHYYESEVLAMNFQ---DWATASRQINSYVKNKTQGKIVDLFSGL 189

  Fly   169 ----------------------LRAE-----LLNDRTEGVIVNGV-------------------- 186
                                  |:|.     :...:.:|.::..|
Human   190 DSPAILVLVNYIFFKGIPTHPHLKAHPLWPGITAAKIQGTLLGKVFDSVKHIHIWESPSSPQSCW 254

  Fly   187 ----SYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDF 247
                .:...|.:.|.|..|.:.:|.......|||..|......:|...:.|..::|::.|.. :.
Human   255 TCLLLFLGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVG-NG 318

  Fly   248 SMLLLLPNRKDGLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMF 312
            ::..:||: |..:.::..:||...:......::..:|::.:||.:::....|....:::|:..:|
Human   319 TVFFILPD-KGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLF 382

  Fly   313 SRDGDFGNMYR--MFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAI 375
            :...:|..:.:  ...|   :.|.|||.:::.|.|||....||:...|.|:......:.||:..|
Human   383 TNQANFSRITQDAQLKS---SKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMI 444

  Fly   376 --KYKDSIAFIGHIAN 389
              .:..|..|:..:.|
Human   445 FDHFTWSSLFLARVMN 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	89/442 (20%)
SERPINA6	XP_047287783.1	serpinA6_CBG	33..461	CDD:381022	89/442 (20%)