DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpini2

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_080736.2	Gene:	Serpini2 / 67931	MGIID:	1915181	Length:	405	Species:	Mus musculus

Alignment Length:	400	Identity:	106/400 - (26%)
Similarity:	189/400 - (47%)	Gaps:	38/400 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLATVSQSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASE 74
            ||..:.||:........||   .|.|||.|::..|.| |::.||......:.:..:||||:...:
Mouse    10 LLFFSGSQTSRATDQKIAD---FAVDLYKAISLSHKN-NIIFSPLGTTMLLGMVQLGAKGKAQQQ 70

  Fly    75 LQQGLRLGPGDA-----------DAVSQRSGSYQQALTRDNNFRLANNIYINENLEFKGSFRDVA 128
            :.:.||:....|           .|:|::...:        .|.||:.:|:.|....|.::....
Mouse    71 ILKTLRMRGTPAGEEFSVLKSLFSAISKKKQEF--------TFNLASALYLQEGFIVKETYLHSN 127

  Fly   129 QRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQ 193
            :..|.|....:||...  |.:|..|:..|.:||:|||.::...|.....|..|:||.:.:...|:
Mouse   128 KEFFQSATKLVDFLDA--KTSAQAISTWVESKTDGKIKNMFSEEEFGPLTRLVLVNAIYFKGDWK 190

  Fly   194 KAFRLDKTEKRSFRTGSGQSVKVDTMWTL--QNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNR 256
            :.||.:.||...|....|.:|||..|..|  ..:.|...:|:..:|:||||:..:||::::||..
Mouse   191 QKFRKEDTEMTDFTKKDGSTVKVPMMKALLRAQYGYFSQSSMTCQVLELPYKADEFSLVIILPTE 255

  Fly   257 KDGLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM 321
            ...:..::..::..::......:.:::|||.||:|.:...|.|:.....|.|..:||...|...:
Mouse   256 DTSIEEVENQVTAPHVRRWFSELHEEEVEVSLPRFKIEQKLDLKEALYSLNVTEIFSGGCDLSGI 320

  Fly   322 ---YRMFVSHFINAVEHKANVEVTEAGVDQPLETGL-LKGLFSRSK-KFEADHPFVFAIKY--KD 379
               ..::||.    |..|...|:.|.|.:....||: :..:.|.:: :|.|:|||:|.:|:  .:
Mouse   321 TDSSEVYVSR----VMQKVFFEINEDGSEAAASTGINIPAIMSLTQTQFLANHPFLFILKHIRTE 381

  Fly   380 SIAFIGHIAN 389
            ||.|:|.:.:
Mouse   382 SILFMGKVTD 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	100/376 (27%)
Serpini2	NP_080736.2	neuroserpin	23..405	CDD:239003	102/386 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030