DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpina5

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001231668.1	Gene:	Serpina5 / 65051	RGDID:	619817	Length:	442	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	101/411 - (24%)
Similarity:	187/411 - (45%)	Gaps:	41/411 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISCLLLLLA--------------TVSQSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPAT 55
            |.||:|..:              ..|:..:||....:.....|..||.|:|::...:||..||.:
  Rat    42 ILCLVLFFSHGVASRQRSHSKEKKKSKESSVGAVGTSRSRDFAFRLYRALASEAPGQNVFFSPMS 106

  Fly    56 IQSSMALAFVGAKGQTASELQQGLRLG--PGDADAVSQRSGSYQQALTRDN------NFRLANNI 112
            :..|:.:..:|:..:|.:::.:||.|.  .|..|.:.:   .:||.|.:.:      ...|.:.:
  Rat   107 VSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQEDMLHK---GFQQLLQQFSQPSDGLQLSLGSAL 168

  Fly   113 YINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDR 177
            :.:..:..:..|....:..:.|::...:|..|.:.:..  ||..||.||||||.|:::.  |:..
  Rat   169 FTDPAVHIRDHFLSAMKTLYMSDMFSTNFGNPESAKKQ--INDYVAKKTNGKIVDLIKD--LDST 229

  Fly   178 TEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPY 242
            ...|:||.:.:.|.||.||....|.|..:.....::::|..|.....::|....::...||.:||
  Rat   230 HVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQVPMMNREDIYSYILDQNISCTVVGIPY 294

  Fly   243 QNPDFSMLLLLPNRKDGLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLG 307
            |...|::.:|....|  ::.::..|..:.|...:...:::::::.|||||:.....||....|||
  Rat   295 QGNTFALFILPSEGK--MKRVEDGLDERTLRNWLKMFTKRQLDLYLPKFSIEGTYKLEKILPKLG 357

  Fly   308 VHTMFSRDGDFGNMYRMFVSHF---INAVEHKANVEVTEAGVDQPLETGLLKGLFS---RSKKFE 366
            :..:|:...|...:    ..|.   ::.:.||:.|||.|:|......||:|..|.|   .|.|.|
  Rat   358 IQDIFTTHADLSGL----TDHTNIKLSEMVHKSMVEVDESGTTAAASTGILFTLRSARPSSLKVE 418

  Fly   367 ADHPFVFAIKYKDSIAFIGHI 387
            ...||:..|....::.|||.:
  Rat   419 FTRPFLVVIMDGTNLYFIGKV 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	94/370 (25%)
Serpina5	NP_001231668.1	alpha-1-antitrypsin_like	81..439	CDD:239011	94/370 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010