DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINB4

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	387	Identity:	106/387 - (27%)
Similarity:	191/387 - (49%)	Gaps:	43/387 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQ-------- 91
            ||:........| |:..||.:|.|::.:..:|||..||.::.:.|..     |.|::
Human    14 DLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQISKVLHF-----DQVTENTTEKAAT 72

  Fly    92 ----RSGS----YQQALTRDN------NFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDF- 141
                |||:    :|:.||..|      ..::||.::..:..:|...:.|..::.:.::::..||
Human    73 YHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFA 137

  Fly   142 HPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSF 206
            :.|...|..  ||..|.::||.||.::.....:.:.|..|:||.:.:...|:..|:.:.|::..|
Human   138 NAPEESRKK--INSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKF 200

  Fly   207 RTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKN 271
            .........|..|....:||:|.:..:.|||:|:||:..|.||::||||..|||:.|::.|:.:.
Human   201 WPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEK 265

  Fly   272 LL--AEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSH--FINA 332
            |:  ..:..|.:..|::.||:|.:.....|:...:.:|:..:|:.|.|...   |..||  .::.
Human   266 LMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSG---MTWSHGLSVSK 327

  Fly   333 VEHKANVEVTEAGVDQPLETGLL---KGLFSRSKKFEADHPFVFAIKYK--DSIAFIGHIAN 389
            |.|||.|||||.||:....|.::   ....|.:::|..:|||:|.|:..  :||.|.|..::
Human   328 VLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	106/383 (28%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	106/387 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930