Protein Alignment Spn43Ab and SERPINB3

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_008850.1
• Gene: SERPINB3 / 6317
• HGNCID: 10569
• Length: 390
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 106/387 - (27%)
• Similarity: 191/387 - (49%)
• Gaps: 43/387 - (11%)

  Fly    35 DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQ-------- 91
            ||:........| |:..||.:|.|::.:..:|||..||.::::.|..     |.|::
Human    14 DLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQIKKVLHF-----DQVTENTTGKAAT 72

  Fly    92 ----RSGS----YQQALTRDN------NFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDF- 141
                |||:    :|:.||..|      ..::||.::..:...|...:.|..::.:.::::.:||
Human    73 YHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFA 137

  Fly   142 HPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSF 206
            :.|...|..  ||..|.::||.||.:::....:...|..|:||.:.:...|:|.|..:.|::..|
Human   138 NAPEESRKK--INSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKF 200

  Fly   207 RTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKN 271
            .........:..|....:|::|.:..:.|||:|:||:..|.||::||||..|||:.|::.|:.:.
Human   201 WPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEK 265

  Fly   272 LL--AEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM--YRMFVSHFINA 332
            |:  ..:..|.:.:|::.||:|.|.....|:...:.:|:..:|:.|.|...|  .|..|   ::.
Human   266 LMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLV---LSG 327

  Fly   333 VEHKANVEVTEAGVDQPLET---GLLKGLFSRSKKFEADHPFVFAIKYK--DSIAFIGHIAN 389
            |.|||.|||||.|.:....|   |......|.:::|..:|||:|.|:..  :||.|.|..::
Human   328 VLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	106/387 (27%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	106/387 (27%)