DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and serpinb14

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	XP_002665111.3	Gene:	serpinb14 / 569051	ZFINID:	ZDB-GENE-050506-148	Length:	437	Species:	Danio rerio

Alignment Length:	437	Identity:	114/437 - (26%)
Similarity:	198/437 - (45%)	Gaps:	78/437 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQ--GLRLGPGDADA 88
            :|.....:.:|:..::..:.:.||..||.:|.|::|:..:||||.||.::.:  |....|..|.|
Zfish     5 SAANTQFSLNLFKKISGGNASGNVFYSPVSISSALAMVSLGAKGNTADQMFKVLGFNNLPKSAGA 69

  Fly    89 VSQ------------RSG---SYQQALTRD--------------------------NNFR----- 107
            ..:            :||   .:.||:.:.                          :||.
Zfish    70 TPEAHQSMMQQAQKPKSGVKDQHGQAMMQQTQKIDIPAELKKGSAVPGQKAEEQIHSNFNKFMSE 134

  Fly   108 -----------LANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTAD--GINRAVAT 159
                       |||.:|..:..:|...|...|:|.:::.::|:||.   ||..|.  .||..|..
Zfish   135 LNKPGAPYVLSLANRLYGEQTYQFVEKFLSDAKRYYEAGLEKVDFK---NKSEAARVNINTWVEK 196

  Fly   160 KTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQN 224
            .|..||.|:|.:..::..|..|:||.:.:...|::.|..:.|....|:....|:..|..|:...:
Zfish   197 NTQEKIKDLLPSGAIDAMTRLVLVNAIYFKGNWERKFPKEATNDGQFKLNKNQTKPVKMMYQKAH 261

  Fly   225 FNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKD----GLRSLQQSLSGKNLL--AEIGAMSQQK 283
            |..|.:..::::|:||||...:.|||::||::.:    ||..|:::|:.:.|:  .:...|.||:
Zfish   262 FPLASIPEMNSQVLELPYVGKNLSMLIILPDQIEDATTGLEKLEKALTYEKLMEWTKPEVMRQQE 326

  Fly   284 VEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSH--FINAVEHKANVEVTEAGV 346
            |:|.||||.:.....::.....:|:..:|  |....|:..|..|:  .::.|.|||.|||.|.|.
Zfish   327 VQVSLPKFKMEQTYDMKSLLVSMGMEDVF--DPQKVNLTGMSSSNDLVLSKVIHKAFVEVNEEGT 389

  Fly   347 DQPLETGLLKGL--FSRSKKFEADHPFVFAIKYK--DSIAFIGHIAN 389
            :....||.:..|  ....:.|.|||||:|.|::.  .||.|.|...:
Zfish   390 EAAAATGAIMMLRCIRLPQSFNADHPFLFFIRHNPTKSILFYGRFCS 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	113/429 (26%)
serpinb14	XP_002665111.3	SERPIN	4..437	CDD:294093	114/437 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930