DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINF2

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	XP_005256758.2	Gene:	SERPINF2 / 5345	HGNCID:	9075	Length:	507	Species:	Homo sapiens

Alignment Length:	383	Identity:	90/383 - (23%)
Similarity:	168/383 - (43%)	Gaps:	53/383 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RNLLA--ADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQ 91
            |.::|  |||::.||......|:::||.::..:::...:||:..|...|||.|..|.|..
Human   100 RAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPC----- 159

  Fly    92 RSGSYQQALTR------DNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTA 150
                ....|:|      ...||||..:|:.:....|..|.:.:::.|.:....|.     .|:..
Human   160 ----LPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLT-----GKQED 215

  Fly   151 D--GINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQS 213
            |  .||:.|...|.|||.:.|..  |.:.|..:::|.:.:...|:..|....|::.||......:
Human   216 DLANINQWVKEATEGKIQEFLSG--LPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFT 278

  Fly   214 VKVDTM--------WTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKD-GLRSLQQSLSG 269
            |.|:.|        |.|       :...:.:|...|::| :.|.::|:|...: .:..:..:||.
Human   279 VPVEMMQARTYPLRWFL-------LEQPEIQVAHFPFKN-NMSFVVLVPTHFEWNVSQVLANLSW 335

  Fly   270 KNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAVE 334
            ..|...:  :.::..:|.|||..:...:.|.....:||:..:|......|...:..|   ::.|:
Human   336 DTLHPPL--VWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLV---VSGVQ 395

  Fly   335 HKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAIKYKDSIA---FIGHIAN 389
            |::.:|::|.||:....|.:.....|.| .|..:.||:|.| ::|:..   |:|.:.|
Human   396 HQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVNRPFLFFI-FEDTTGLPLFVGSVRN 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	88/378 (23%)
SERPINF2	XP_005256758.2	alpha2AP	98..449	CDD:239008	89/379 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010