DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINI1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	399	Identity:	101/399 - (25%)
Similarity:	195/399 - (48%)	Gaps:	33/399 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLATVSQSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTAS 73
            ||:|.:::...|...:|.||   |:.::||.:.|...:||::.||.:|..:|.:..:||:|.|..
Human     9 LLVLQSMATGATFPEEAIAD---LSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQK 70

  Fly    74 ELQQGL---RLGPGDADAVSQRSGSYQQALTRDNNFRLANNIYINENLEFKGSFRDVAQRQFDSN 135
            |::..:   .|..|:..:..:...:...|.......::||::::.........|..:.::.|::.
Human    71 EIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAA 135

  Fly   136 IDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDK 200
            ::.:||  ..|...|:.||:.|...||..:.|::.....:..|...::|.|.:...|:..||.:.
Human   136 VNHVDF--SQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPEN 198

  Fly   201 TEKRSFRTGSGQSVKVDTMWTLQNFNYAEVN--SLDA----KVVELPYQNPDFSMLLLLPNRKDG 259
            |...||.......|::..|:....|.|.|.:  |.:|    :|:|:||:..:.||:|:|..::..
Human   199 TRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVP 263

  Fly   260 LRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM--- 321
            |.:|:..:..:.:.....::.:|||||.||:|:|...:.|:...|.||:..:|.:|.:...:
Human   264 LATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDN 328

  Fly   322 YRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSK------KFEADHPFVFAIKYK-- 378
            ..:|:|..|    ||:.:||.|.|    .|...:.|:.:.|:      :...||||.|.|:.:
Human   329 KEIFLSKAI----HKSFLEVNEEG----SEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRT 385

  Fly   379 DSIAFIGHI 387
            .:|.|:|.:
Human   386 GTILFMGRV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	94/376 (25%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	97/385 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030