Protein Alignment Spn43Ab and SERPINE2

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_005246698.1
• Gene: SERPINE2 / 5270
• HGNCID: 8951
• Length: 410
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 109/404 - (26%)
• Similarity: 185/404 - (45%)
• Gaps: 40/404 - (9%)

  Fly     9 LLLLATVSQSKTVGYDAAADRNLLAAD----LYNAVAADHLNENVVISPATIQSSMALAFVGAKG 69
            |.|||:|:......:........|.::    ::|.:.....::|:||||..|.|.:.:..:||.|
Human    19 LFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADG 83

  Fly    70 QTASELQQGLRLGPGDADAVSQRSGSYQQALTRDNN---FRLANNIYINENLEFKGSF----RDV 127
            :|..:|...:|.|   .:.|.:......:|:....|   ..:||.:::....|.:..|    :||
Human    84 RTKKQLAMVMRYG---VNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDV 145

  Fly   128 AQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLND-RTEGVIVNGVSYSAA 191
                |...:..::|..|.:  ..|.||..|..:|...|.::|..:|::. .|..|:||.|.:...
Human   146 ----FQCEVRNVNFEDPAS--ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGL 204

  Fly   192 WQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEV---NSLDAKVVELPYQNPDFSMLLLL 253
            |:..|:.:.|:||:|....|:|.:|..:..|..|.....   |.|....:||||.....|||:.|
Human   205 WKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIAL 269

  Fly   254 PNRKD-GLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMF-SRDG 316
            |.... .|.::...:|.|.:.:.:..|..::|:|:||||:......|:.|.|.||:..|| |...
Human   270 PTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 334

  Fly   317 DFGNM----YRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKK--FEADHPFVFAI 375
            :|..:    ..:.|||.:    .||.:||:|.|......|..:  |.:||..  |..|.||:|.|
Human   335 NFAKITTGSENLHVSHIL----QKAKIEVSEDGTKASAATTAI--LIARSSPPWFIVDRPFLFFI 393

  Fly   376 KYK--DSIAFIGHI 387
            ::.  .::.|:|.|
Human   394 RHNPTGAVLFMGQI 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	104/386 (27%)
SERPINE2	XP_005246698.1	serpinE2_GDN	33..408	CDD:381039	104/390 (27%)