Protein Alignment Spn43Ab and SERPINB6

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_011512974.1
• Gene: SERPINB6 / 5269
• HGNCID: 8950
• Length: 454
• Species: Homo sapiens
• Alignment Length: 422
• Identity: 117/422 - (27%)
• Similarity: 206/422 - (48%)
• Gaps: 46/422 - (10%)

  Fly     2 AVIISCLLLLLATVSQ--------------SKTVGYDAAADRN-LLAADLYNAVAADHLNENVVI 51
            ||:.:.|||....|:|              .|:...|..|:.| ..|.:|...:..|: ::||..
Human    44 AVMFAHLLLTSCCVAQFLTDHRRICWGLLHIKSAIMDVLAEANGTFALNLLKTLGKDN-SKNVFF 107

  Fly    52 SPATIQSSMALAFVGAKGQTASELQQGLRL----GPGDADAVSQRSGSYQQALTRDNN------F 106
            ||.::..::|:.::||||.||:::.|.|..    |.||   :.|   .:|..||..|.      .
Human   108 SPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGD---IHQ---GFQSLLTEVNKTGTQYLL 166

  Fly   107 RLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRA 171
            |:||.::..::.:|..||||..|:.:.:.:::|||.....| :...||..||.||.|||.::|..
Human   167 RMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEK-SRKHINTWVAEKTEGKIAELLSP 230

  Fly   172 ELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAK 236
            ..::..|..|:||.|.:...|.:.|..:.||:|.|:....:...|..|:....|....:..:..:
Human   231 GSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQ 295

  Fly   237 VVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLL--AEIGAMSQQKVEVLLPKFSVTFGLGL 299
            ::.|||...:.:|:::||:....||::::.|:.:..:  ..:..|.:::|||.||:|.:.....:
Human   296 ILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDM 360

  Fly   300 EGPFKKLGVHTMFS-RDGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSK 363
            |...:.||:...|. ...||..|.:..:|  ::.|.||:.|||.|.|.:....|..:  :..|..
Human   361 ESVLRNLGMTDAFELGKADFSGMSQTDLS--LSKVVHKSFVEVNEEGTEAAAATAAI--MMMRCA 421

  Fly   364 KFE----ADHPFVFAIKYK--DSIAFIGHIAN 389
            :|.    |||||:|.|::.  :.|.|.|..::
Human   422 RFVPRFCADHPFLFFIQHSKTNGILFCGRFSS 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	108/383 (28%)
SERPINB6	XP_011512974.1	serpinB6_CAP	79..454	CDD:381031	109/387 (28%)