DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINB6

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	XP_011512974.1	Gene:	SERPINB6 / 5269	HGNCID:	8950	Length:	454	Species:	Homo sapiens

Alignment Length:	422	Identity:	117/422 - (27%)
Similarity:	206/422 - (48%)	Gaps:	46/422 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVIISCLLLLLATVSQ--------------SKTVGYDAAADRN-LLAADLYNAVAADHLNENVVI 51
            ||:.:.|||....|:|              .|:...|..|:.| ..|.:|...:..|: ::||..
Human    44 AVMFAHLLLTSCCVAQFLTDHRRICWGLLHIKSAIMDVLAEANGTFALNLLKTLGKDN-SKNVFF 107

  Fly    52 SPATIQSSMALAFVGAKGQTASELQQGLRL----GPGDADAVSQRSGSYQQALTRDNN------F 106
            ||.::..::|:.::||||.||:::.|.|..    |.||   :.|   .:|..||..|.      .
Human   108 SPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGD---IHQ---GFQSLLTEVNKTGTQYLL 166

  Fly   107 RLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRA 171
            |:||.::..::.:|..||||..|:.:.:.:::|||.....| :...||..||.||.|||.::|..
Human   167 RMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEK-SRKHINTWVAEKTEGKIAELLSP 230

  Fly   172 ELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAK 236
            ..::..|..|:||.|.:...|.:.|..:.||:|.|:....:...|..|:....|....:..:..:
Human   231 GSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQ 295

  Fly   237 VVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLL--AEIGAMSQQKVEVLLPKFSVTFGLGL 299
            ::.|||...:.:|:::||:....||::::.|:.:..:  ..:..|.:::|||.||:|.:.....:
Human   296 ILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDM 360

  Fly   300 EGPFKKLGVHTMFS-RDGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSK 363
            |...:.||:...|. ...||..|.:..:|  ::.|.||:.|||.|.|.:....|..:  :..|..
Human   361 ESVLRNLGMTDAFELGKADFSGMSQTDLS--LSKVVHKSFVEVNEEGTEAAAATAAI--MMMRCA 421

  Fly   364 KFE----ADHPFVFAIKYK--DSIAFIGHIAN 389
            :|.    |||||:|.|::.  :.|.|.|..::
Human   422 RFVPRFCADHPFLFFIQHSKTNGILFCGRFSS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	107/376 (28%)
SERPINB6	XP_011512974.1	PAI-2	82..454	CDD:239013	108/384 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930