DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINF1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	375	Identity:	77/375 - (20%)
Similarity:	155/375 - (41%)	Gaps:	31/375 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NLLAA-------DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDAD 87
            |.|||       |||...::.....||::||.::.::::...:||:.:|.|.:.:.|..     |
Human    52 NKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYY-----D 111

  Fly    88 AVSQRS--GSYQQAL----TRDNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYN 146
            .:|...  |:|::.|    ....|.:.|:.|...:.|..|.||....::.:.:....|..:|
Human   112 LISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNP--- 173

  Fly   147 KRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSG 211
            :.....||..|..:..||:....:.  :.|....:::....:...|...|...||....|.....
Human   174 RLDLQEINNWVQAQMKGKLARSTKE--IPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEE 236

  Fly   212 QSVKVDTMWTLQN-FNYAEVNSLDAKVVELPYQNPDFSMLLLLPNR-KDGLRSLQQSLSGKNLLA 274
            ::|:|..|...:. ..|...:.|..|:.:||... ..|::..||.: ...|..:::||:.:.:..
Human   237 RTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTG-SMSIIFFLPLKVTQNLTLIEESLTSEFIHD 300

  Fly   275 EIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAVEHKANV 339
            ....:...:..:.:||..:::...:....:::.:.::|. ..||..:....:.  :..|||:|..
Human   301 IDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFD-SPDFSKITGKPIK--LTQVEHRAGF 362

  Fly   340 EVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAIKYKD--SIAFIGHI 387
            |..|.|.......||.....:....:..:.||:|.::..|  ::.|||.|
Human   363 EWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	76/373 (20%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	77/375 (21%)
		O-glycosylated at one site	371..383		2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010