DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINB2

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001137290.1	Gene:	SERPINB2 / 5055	HGNCID:	8584	Length:	415	Species:	Homo sapiens

Alignment Length:	418	Identity:	112/418 - (26%)
Similarity:	191/418 - (45%)	Gaps:	58/418 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DAAADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADA 88
            |......|.|.:|:..:|.....:|:.:||.:|.|:||:.::|::|.|..::.:.|:.....|:|
Human     3 DLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANA 67

  Fly    89 VSQ---------------RSGSYQQALTR-------DNNFR-LANNI------YINENL-----E 119
            |:.               :.|||..|:.:       .::|| |::.|      |:.|::     |
Human    68 VTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGE 132

  Fly   120 FKGSFRD----VAQRQFDSN---IDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDR 177
            ...|||:    :.|:.:.|.   :|.|:......|:    ||..|.|:|.|||.::|....::..
Human   133 KSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKK----INSWVKTQTKGKIPNLLPEGSVDGD 193

  Fly   178 TEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPY 242
            |..|:||.|.:...|:..|.........||..|.|...|..|:..:..|...:..|.|:::||||
Human   194 TRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPY 258

  Fly   243 QNPDFSMLLLLPNR----KDGLRSLQQSLS--GKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEG 301
            .. |.||.||||:.    ..||..|:..::  ..|.......|::.:|||.:|:|.:.....|..
Human   259 AG-DVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRS 322

  Fly   302 PFKKLGVHTMFSRD-GDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLET-GLLKGLFSR-SK 363
            ..:.:|:...|::. .:|..|... ...|::.|.|:|.|:|.|.|.:....| |::.|.... ..
Human   323 ILRSMGMEDAFNKGRANFSGMSER-NDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGP 386

  Fly   364 KFEADHPFVFAIKYK--DSIAFIGHIAN 389
            :|.|||||:|.|.:|  :.|.|.|..::
Human   387 QFVADHPFLFLIMHKITNCILFFGRFSS 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	111/408 (27%)
SERPINB2	NP_001137290.1	PAI-2	4..415	CDD:239013	111/417 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930