Protein Alignment Spn43Ab and SERPINE1

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_001373389.1
• Gene: SERPINE1 / 5054
• HGNCID: 8583
• Length: 492
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 102/405 - (25%)
• Similarity: 174/405 - (42%)
• Gaps: 48/405 - (11%)

  Fly     1 MAVIISCLLLLLATVSQSKTVGYDAAADRNLLAAD----LYNAVAADHLNENVVISPATIQSSMA 61
            |:..::||:|.||.|....:..:...:....||:|    ::..||....:.|||.||..:.|.:|
Human     3 MSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLA 67

  Fly    62 LAFVGAKGQTASELQQGL-------------------RLGPGDADAVSQRSGSYQQALTRDNNFR 107
            :..:...|:|..::|..:                   .:||.:.|.:|          |.|
Human    68 MLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEIS----------TTD---- 118

  Fly   108 LANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAE 172
               .|::..:|:....|.....|.|.|.:.::||......|..  ||..|.|.|.|.|:::|...
Human   119 ---AIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFI--INDWVKTHTKGMISNLLGKG 178

  Fly   173 LLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDA-- 235
            .::..|..|:||.:.::..|:..|....|.:|.|....|.:|.|..|.....|||.|..:.|.
Human   179 AVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHY 243

  Fly   236 -KVVELPYQNPDFSMLLLLPNRKD-GLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLG 298
             .::||||.....||.:..|..|: .|.:|...||.:.:....|.|::....::|||||:...:.
Human   244 YDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVD 308

  Fly   299 LEGPFKKLGVHTMFSR-DGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRS 362
            |..|.:.||:..||.: ..||.::......|...|:: |..:||.|:|......|.::.......
Human   309 LRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQ-KVKIEVNESGTVASSSTAVIVSARMAP 372

  Fly   363 KKFEADHPFVFAIKY 377
            ::...|.||:|.:::
Human   373 EEIIMDRPFLFVVRH 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	95/379 (25%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	95/379 (25%)