DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn43Ab and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	102/406 - (25%)
Similarity:	184/406 - (45%)	Gaps:	35/406 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLLLLATVSQSKTVGYDA-------------AADRNL-LAADLYNAVAADHLNENVVISPATIQ 57
            |||.:.......|.|...|             .|:|:. ||..||.|:|.|...||:::||..:.
  Rat    10 CLLAVALAAEVKKPVEATAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVA 74

  Fly    58 SSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGSYQQALT----RDNNFRLANNIYINENL 118
            ||:.|..:|.|..|||:.:..|.......:.|....|...::|:    |:..::|.:.:|...::
  Rat    75 SSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSV 139

  Fly   119 EFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTA-DGINRAVATKTNGKITDILRAELLNDRTEG-V 181
            .|...|...:::.::....|::|.   :||:| ..||...:..|:||:.::.:..   :||:| :
  Rat   140 SFADDFVRSSKQHYNCEHSKINFR---DKRSALQSINEWASQTTDGKLPEVTKDV---ERTDGAL 198

  Fly   182 IVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPD 246
            :||.:.:...|.:.|.....:.|.|......:|.|..|.....:||.:......::||:|..:..
  Rat   199 LVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKL 263

  Fly   247 FSMLLLLPNRKDGLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTM 311
            .|:::|:|:..:.|..|::.|:.:.|...:|.|.::.|.:.|||..|.....|:.....||:...
  Rat   264 SSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEA 328

  Fly   312 FSRDGDFGNMYRMFVSH--FINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKK-FEADHPFVF 373
            .  |.:..::.||....  ::.:|.|....|....|  .|.:..:......||.| |.|||||:|
  Rat   329 I--DKNKADLSRMSGKKDLYLASVFHATAFEWDTEG--NPFDQDIYGREELRSPKLFYADHPFIF 389

  Fly   374 AIK--YKDSIAFIGHI 387
            .::  ...|:.|||.:
  Rat   390 LVRDNQSGSLLFIGRL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	94/368 (26%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	96/381 (25%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010