DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpinb10

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_714955.2	Gene:	Serpinb10 / 266775	RGDID:	628853	Length:	397	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	108/401 - (26%)
Similarity:	187/401 - (46%)	Gaps:	54/401 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGL--------RLG 82
            |...|..|.:....:|......|:..||..|.:|:|:.::|.||.||:::.|.|        :.|
  Rat     5 AVSINQFAVEFSKKLAESAEGRNIFFSPWGISTSLAMVYLGTKGTTAAQMSQVLHFGSIQDFKFG 69

  Fly    83 PGDADAVSQR-----SGSYQ------QALT-----RDNNF--RLANNIYINENLEFKGSFRDVAQ 129
            |   |:..:|     ||..:      |.||     ..|::  ::||.||:.:...|...:.:..:
  Rat    70 P---DSEKKRKMECHSGKSEEIQSDFQTLTAKILKHGNSYVLKIANRIYVEKTYLFHNKYLEDMK 131

  Fly   130 RQFDSNIDKLDFHPPYNKRTADG-----INRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYS 189
            ..|.:....::|      ..|.|     ||..|.::|.|||.::|..:.::::|..|:||.:.:.
  Rat   132 TYFGAEPQSVNF------VEASGQIRKEINSWVGSQTGGKIPNLLPDDAVDNKTTMVLVNALYFK 190

  Fly   190 AAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLP 254
            ..|:..|.:..|.:|.||.....|..|..|...|:.....:..|....|:|.|||.:||:|||||
  Rat   191 GTWEHQFSVQNTTERPFRINKTTSKPVQMMSMKQSLQVFHIEELQTIGVQLHYQNREFSLLLLLP 255

  Fly   255 NRKDGLRSLQQSLSGKNL--LAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSR-DG 316
            ...:||:.|:::::.:.|  ......|...:|::.||||.:.....|:...:.:|:...|:: ..
  Rat   256 EEVEGLKQLERAITYEKLDKWTSADMMDTYEVQLYLPKFKMEESYDLQSALRDMGMTDAFNQGKA 320

  Fly   317 DFGNM---YRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKKFE--ADHPFVFAIK 376
            :|.||   ..:|:|:    |.||..:|:.|.|.:....||.......::...|  |||||:|.|:
  Rat   321 NFSNMTSERNLFLSN----VFHKTFLEINEEGTEAAAGTGSEVNFRIKAPSIELNADHPFLFLIR 381

  Fly   377 YK--DSIAFIG 385
            :.  ::|.|.|
  Rat   382 HNVTNTILFYG 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	107/397 (27%)
Serpinb10	NP_714955.2	SERPIN	4..397	CDD:294093	108/401 (27%)
Serpinb10	NP_714955.2	Nuclear localization signal. /evidence=ECO:0000250	74..77		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930