DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpina4

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_659565.2	Gene:	Serpina4 / 246328	RGDID:	708581	Length:	423	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	103/432 - (23%)
Similarity:	178/432 - (41%)	Gaps:	66/432 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLLLLATV------------------------SQSKTVGYDAAADRNLLAADLYNAVAADHLNE 47
            |||||||.:                        ||.....|..|:.....|..||:.:|:.:..:
  Rat     6 CLLLLLAGLLELSHSQPDQEEPDNTTNQTYRQFSQQNISSYQIASGNANFAFRLYHLIASQNSEK 70

  Fly    48 NVVISPATIQSSMALAFVGAKGQTASELQQGL--RLGPGDADAVSQRSGSYQQALTR---DNNFR 107
            |:..||.:|..|:|:...||.|.|.:::.:||  .|.......:.:...|.|..:.|   :....
  Rat    71 NIFFSPLSISVSLAILSTGAGGDTQAQILEGLGFNLTKLSLPEIHEGFRSLQHTIARPFTEPQIS 135

  Fly   108 LANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTA-DGINRAVATKTNGKITDILRA 171
            :.:.:.:::||:....|....:..::|.:...:|.   :|..| ..||..|...|.|||.::: :
  Rat   136 VGSALILSQNLQILSEFVSAIETSYNSKVLHANFR---DKEAAVQLINNYVKQNTQGKIKNLV-S 196

  Fly   172 ELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTM-------WTLQNFNYAE 229
            :|..| .:.|:||.:.:...|:|.|...:.....|.......||:..|       |      |.|
  Rat   197 DLSPD-VKMVLVNYIFFQGLWKKPFPSSRVSTSDFYVDENTVVKIPMMLQDKEDHW------YLE 254

  Fly   230 VNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLS------GKNLLAEIGAMSQQKVEVLL 288
            ...:...|:.:.|:. |.....:||: :..:..::|.||      .|.||.  .....:|:.:.|
  Rat   255 DRRVPCTVLRMDYRG-DAVAFFILPD-QGKMNEVEQVLSPGMLLRWKRLLQ--NRFFYRKLILQL 315

  Fly   289 PKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETG 353
            ||||::....|:.....||...:|:.:.:|.|:.:. ...:::.|.||..::|.|.|......||
  Rat   316 PKFSISNSYELDEILPDLGFQDLFTPNANFSNISKK-EKLYLSKVFHKTVLDVNEVGTKAAAATG 379

  Fly   354 LLKGLFSRSKK---FEADHPFVFAIKYKDS---IAFIGHIAN 389
            .....||...|   ...:.||: .|.|..|   |.|:|.:.|
  Rat   380 SFATFFSAQPKKRYLIFNRPFL-VILYSTSSQDILFMGKVVN 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	91/381 (24%)
Serpina4	NP_659565.2	SERPIN	52..418	CDD:294093	91/382 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110