DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpine2

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_033281.1	Gene:	Serpine2 / 20720	MGIID:	101780	Length:	397	Species:	Mus musculus

Alignment Length:	406	Identity:	106/406 - (26%)
Similarity:	188/406 - (46%)	Gaps:	49/406 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLATVSQSKTVGYDAAADRNLLAAD---------LYNAVAADHLNENVVISPATIQSSMALAFVG 66
            :|.||:.     |...:..|.|:.:         ::|.:.....:||||:||..|.|.:.:..:|
Mouse     9 ILTTVTL-----YSVHSQFNSLSLEELGSNTGIQVFNQIIKSRPHENVVVSPHGIASILGMLQLG 68

  Fly    67 AKGQTASELQQGLRLGPGDADAVSQRSGSYQQALTRDNN---FRLANNIYINENLEFKGSF---- 124
            |.|:|..:|...:|.   :.:.|.:......:|:....|   ..:||.:::....:.:..|
Mouse    69 ADGKTKKQLSTVMRY---NVNGVGKVLKKINKAIVSKKNKDIVTVANAVFLRNGFKMEVPFAVRN 130

  Fly   125 RDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDR-TEGVIVNGVSY 188
            :||    |...:..::|..|.:  .::.||..|..:|.|.|.::|...|::.. |..|:||.|.:
Mouse   131 KDV----FQCEVQNVNFQDPAS--ASESINFWVKNETRGMIDNLLSPNLIDGALTRLVLVNAVYF 189

  Fly   189 SAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEV---NSLDAKVVELPYQNPDFSML 250
            ...|:..|:.:.|:||:|..|.|:|.:|..:..|..|.....   |.|....:||||.....|||
Mouse   190 KGLWKSRFQPESTKKRTFVAGDGKSYQVPMLAQLSVFRSGSTRTPNGLWYNFIELPYHGESISML 254

  Fly   251 LLLPNRKD-GLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFS- 313
            :.||.... .|.::...::.|.:.:.:..|..::::::||||:......|:.|.|.||:..||.
Mouse   255 IALPTESSTPLSAIIPHITTKTIDSWMNTMVPKRMQLVLPKFTAVAQTDLKEPLKALGITEMFEP 319

  Fly   314 RDGDFGNMYR---MFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKK--FEADHPFVF 373
            ...:|..:.|   :.|||.:    .||.:||:|.|......|..:  |.:||..  |..|.||:|
Mouse   320 SKANFTKITRSESLHVSHIL----QKAKIEVSEDGTKASAATTAI--LIARSSPPWFIVDRPFLF 378

  Fly   374 AIKYK--DSIAFIGHI 387
            :|::.  .:|.|:|.:
Mouse   379 SIRHNPTGAILFLGQV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	102/385 (26%)
Serpine2	NP_033281.1	serpinE2_GDN	21..395	CDD:381039	102/389 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030